Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species

被引：4
作者：
Schell, Wiley A. [1 ]
Jones, A. M. [2 ]
Borroto-Esoda, Katyna [3 ]
Alexander, Barbara D. [1 ]
机构：
[1] Duke Univ, Med Ctr, Dept Med, Div Infect Dis, Durham, NC 27710 USA
[2] NHGRI, Computat Genom Unit, NIH, Bethesda, MD 20892 USA
[3] Scynexis Inc, Jersey City, NJ USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 11期
关键词：
Candida; antifungal agents; antifungal resistance; GLUCAN SYNTHASE INHIBITOR; INVASIVE CANDIDIASIS; ECHINOCANDIN RESISTANCE; UNITED-STATES; INFECTIONS; MUTATIONS; EPIDEMIOLOGY; OUTCOMES; MK-3118; SPP;
D O I：
10.1128/AAC.01102-17
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
SCY-078 in vitro activity was determined for 178 isolates of resistant or susceptible Candida albicans, Candida dubliniensis, Candida glabrata, Candida krusei, Candida lusitaniae, and Candida parapsilosis, including 44 Candida isolates with known genotypic (FKS1 or FKS2 mutations), phenotypic, or clinical resistance to echinocandins. Results were compared to those for anidulafungin, caspofungin, micafungin, fluconazole, and voriconazole. SCY-078 was shown to have excellent activity against both wild-type isolates and echinocandin- and azole-resistant isolates of Candida species.
引用
收藏
页数：6
相关论文
共 24 条
[1]   Increasing Echinocandin Resistance in Candida glabrata: Clinical Failure Correlates With Presence of FKS Mutations and Elevated Minimum Inhibitory Concentrations [J].
Alexander, Barbara D. ;
Johnson, Melissa D. ;
Pfeiffer, Christopher D. ;
Jimenez-Ortigosa, Cristina ;
Catania, Jelena ;
Booker, Rachel ;
Castanheira, Mariana ;
Messer, Shawn A. ;
Perlin, David S. ;
Pfaller, Michael A. .
CLINICAL INFECTIOUS DISEASES, 2013, 56 (12) :1724-1732
[2]   Cost of Invasive Fungal Infections in the Era of New Diagnostics and Expanded Treatment Options [J].
Ashley, Elizabeth Dodds ;
Drew, Richard ;
Johnson, Melissa ;
Danna, Robert ;
Dabrowski, Dominika ;
Walker, Valery ;
Prasad, Manishi ;
Alexander, Barbara ;
Papadopoulos, George ;
Perfect, John .
PHARMACOTHERAPY, 2012, 32 (10) :890-901
[3]  
Clinical and Laboratory Standards Institute, 2012, M27S4 CLIN LAB STAND
[4]  
Clinical and Laboratory Standards Institute, 2008, REF METH BROTH DIL A
[5]  
Clinical and Laboratory Standards Institute, 2017, M59 CLIN LAB STAND I
[6]   A first Portuguese epidemiological survey of fungaemia in a university hospital [J].
Costa-de-Oliveira, S. ;
Pina-Vaz, C. ;
Mendonca, D. ;
Rodrigues, A. Goncalves .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2008, 27 (05) :365-374
[7]  
Dudiuk C, 2017, ANTIMICROB AGENTS CH, V61, DOI [10.1128/AAC.02644-16, 10.1128/aac.02644-16]
[8]   Set of Classical PCRs for Detection of Mutations in Candida glabrata FKS Genes Linked with Echinocandin Resistance [J].
Dudiuk, Catiana ;
Gamarra, Soledad ;
Leonardeli, Florencia ;
Jimenez-Ortigosa, Cristina ;
Vitale, Roxana G. ;
Afeltra, Javier ;
Perlin, David S. ;
Garcia-Effron, Guillermo .
JOURNAL OF CLINICAL MICROBIOLOGY, 2014, 52 (07) :2609-2614
[9]   A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibility [J].
Garcia-Effron, Guillermo ;
Katiyar, Santosh K. ;
Park, Steven ;
Edlind, Thomas D. ;
Perlin, David S. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (07) :2305-2312
[10]   Effect of Candida glabrata FKS1 and FKS2 Mutations on Echinocandin Sensitivity and Kinetics of 1,3-β-D-Glucan Synthase: Implication for the Existing Susceptibility Breakpoint [J].
Garcia-Effron, Guillermo ;
Lee, Samuel ;
Park, Steven ;
Cleary, John D. ;
Perlin, David S. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (09) :3690-3699
123