Progressive brachial plexus enlargement in hereditary transthyretin amyloidosis

被引：14

作者：

Salvalaggio, Alessandro ^{[1
,2
]}

Coraci, Daniele ^{[3
]}

Obici, Laura ^{[4
]}

Cacciavillani, Mario ^{[5
]}

Luigetti, Marco ^{[6
,7
]}

Mazzeo, Anna ^{[8
]}

Pastorelli, Francesca ^{[9
]}

Grandis, Marina ^{[10
,11
]}

Cavallaro, Tiziana ^{[12
]}

Bisogni, Giulia ^{[13
]}

Lozza, Alessandro ^{[4
]}

Gemelli, Chiara ^{[10
]}

Gentile, Luca ^{[8
]}

Russo, Massimo ^{[8
]}

Ermani, Mario ^{[1
]}

Fabrizi, Gian Maria ^{[12
]}

Plasmati, Rosaria ^{[9
]}

De Napoli, Federica ^{[1
]}

Campagnolo, Marta ^{[1
]}

Castellani, Francesca ^{[1
]}

Salvi, Fabrizio ^{[9
]}

Fenu, Silvia ^{[14
]}

Devigili, Grazia ^{[15
]}

Pareyson, Davide ^{[14
]}

Gasparotti, Roberto ^{[16
]}

Rapezzi, Claudio ^{[17
,18
]}

Martinoli, Carlo ^{[11
,19
]}

Padua, Luca ^{[3
,7
]}

Briani, Chiara ^{[1
]}

机构：

[1] Univ Padua, Dept Neurosci, Via Giustiniani 5, I-35128 Padua, Italy

[2] Univ Padua, Padova Neurosci Ctr PNC, Padua, Italy

[3] Fdn Policlin Univ A Gemelli IRCCS, Neuroriabilitaz Ad Alta Intensita, Rome, Italy

[4] Fdn IRCCS Policlin San Matteo, Amyloidosis Res & Treatment Ctr, Pavia, Italy

[5] Synlab Grp, CEMES EMG Lab, Padua, Italy

[6] Fdn Policlin Univ Gemelli IRCCS, Neurol Unit, Rome, Italy

[7] Univ Cattolica Sacro Cuore, Dept Geriatr Neurosci & Orthopaed, Rome, Italy

[8] Univ Messina, Unit Neurol & Neuromuscular Dis, Dept Clin & Expt Med, Messina, Italy

[9] Bellaria Hosp, Div Neurol, IRCCS Inst Neurol Sci, Bologna, Italy

[10] Univ Genoa, Dept Neurosci Rehabil Ophthalmol Genet Maternal &, Genoa, Italy

[11] Osped Policlin San Martino IRCCS, Genoa, Italy

[12] Univ Verona, Neurol Unit, Dept Neurosci Biomed & Movement Sci, Verona, Italy

[13] Ctr Clin NEMO Adulti, Rome, Italy

[14] Fdn IRCCS Ist Neurol Carlo Besta, Rare Neurodegenerat & Neurometab Dis Unit, Dept Clin Neurosci, Milan, Italy

[15] Fdn IRCCS Ist Neurol Carlo Besta, Neurol Unit 1, Dept Clin Neurosci, Milan, Italy

[16] Univ Brescia, Dept Med & Surg Specialties Radiol Sci & Publ Hlt, Brescia, Italy

[17] Univ Ferrara, Ctr Cardiol, Ferrara, Italy

[18] GVM Care & Res, Maria Cecilia Hosp, Cotignola, RA, Italy

[19] Univ Genoa, Dept Sci Salute, Genoa, Italy

来源：

JOURNAL OF NEUROLOGY | 2022年 / 269卷 / 04期

关键词：

Amyloidosis; Transthyretin; Brachial plexus; Ultrasound; Peripheral nerves; NERVE INJURY; POLYNEUROPATHY;

D O I：

10.1007/s00415-021-10754-9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Axonal polyneuropathy is the main feature of hereditary transthyretin amyloidosis (ATTRv). Nerve morphological abnormalities have been reported, but longitudinal changes have never been assessed. We performed a prospective widespread nerve ultrasound evaluation and nerve cross-sectional area (CSA) was compared with baseline data in both ATTRv patients and pre-symptomatic carriers. Thirty-eight subjects were evaluated (mean follow-up 17.1 months), among them 21 had polyneuropathy while 17 were pre-symptomatic carriers. CSA significantly increased at brachial plexus in both groups (p = 0.008 and p = 0.012) pointing to progressive brachial plexus enlargement as a longitudinal biomarker of both disease progression and disease occurrence in pre-symptomatic carriers.

引用

页码：1905 / 1912

页数：8

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