Medication compliance and clinical outcomes of fixed-dose combinations vs free combinations of an angiotensin II receptor blocker and a calcium channel blocker in hypertension treatment

被引：14

作者：

Tung, Ying-Chang ^{[1
]}

Huang, Yu-Chang ^{[1
]}

Wu, Lung-Sheng ^{[1
]}

Chang, Chee-Jen ^{[3
]}

Chu, Pao-Hsien ^{[1
,2
,4
]}

机构：

[1] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Cardiol, Taipei, Taiwan

[2] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Healthcare Ctr, Taipei, Taiwan

[3] Chang Gung Univ, Coll Med, Clin Informat & Med Stat Res Ctr, Taipei, Taiwan

[4] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Heart Failure Ctr, Taipei, Taiwan

来源：

JOURNAL OF CLINICAL HYPERTENSION | 2017年 / 19卷 / 10期

关键词：

angiotensin II receptor blocker; dihydropyridine calcium channel blocker; fixed-dose combination; hypertension; major adverse cardiac event; CONVERTING ENZYME-INHIBITORS; BLOOD-PRESSURE CONTROL; GLOBAL BURDEN; RISK-FACTORS; ADHERENCE; PREVENTION; MANAGEMENT; REDUCTION; DISEASE; TRIAL;

D O I：

10.1111/jch.13035

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Using the National Health Insurance Research Database of Taiwan, the authors identified 1136 patients taking fixed-dose combination and 4544 patients taking free combinations of an angiotensin II receptor blocker and a dihydropyridine calcium channel blocker from January 2009 to December 2012. At a mean follow-up of 2.1years, the fixed-dose combination was associated with improved medication adherence and persistence and better survival free from major adverse cardiac events and hospitalization for heart failure compared with the free combination regimens.

引用

页码：983 / 989

页数：7

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