N-Acylsulfonamide Assisted Tandem C-H Olefination/Annulation: Synthesis of Isoindolinones

被引：153

作者：

Zhu, Chen ^{[1
]}

Falck, J. R. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Biochem & Pharmacol, Dallas, TX 75390 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 05期

关键词：

PALLADIUM-CATALYZED CYCLIZATION; PD(II)-CATALYZED OLEFINATION; BOND FUNCTIONALIZATION; AROMATIC-SUBSTITUTION; ROOM-TEMPERATURE; DIRECT ARYLATION; BENZOIC-ACIDS; INDOLES; MECHANISM; ALKENYLATION;

D O I：

10.1021/ol200093f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A tandem C-H olefination/annulation sequence directed by N-acylsulfonamides affords a variety of isoindolinones. This transformation is compatible with aliphatic alkenes as well as conjugated alkenes. Notably, molecular oxygen can be used as the sole, eco-friendly oxidant.

引用

页码：1214 / 1217

页数：4

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