Antifungal and antioxidant activity of fatty acid methyl esters from vegetable oils

被引：115

作者：

Pinto, Maria E. A. ^{[1
]}

Araujo, Sthefane G. ^{[1
]}

Morais, Marcela I. ^{[1
]}

Sa, Nivea P. ^{[2
]}

Lima, Caroline M. ^{[2
]}

Rosa, Carlos A. ^{[2
]}

Siqueira, Ezequias P. ^{[3
]}

Johann, Susana ^{[2
]}

Lima, Luciana A. R. S. ^{[1
]}

机构：

[1] Univ Fed Sao Joao Del Rei, Campus Ctr Oeste Dona Lindu, BR-35501296 Divinopolis, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Microbiol, Inst Ciencias Biol, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil

[3] Ctr Pesquisas Rene Rachou Fiocruz, Ave Augusto Lima 1715, BR-30190002 Belo Horizonte, MG, Brazil

来源：

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS | 2017年 / 89卷 / 03期

关键词：

antifungal; antioxidant; fatty acid methyl esters; vegetable oils; FUNGUS PARACOCCIDIOIDES-BRASILIENSIS; HIL; ANNONACEAE; SEEDS; ANTIBACTERIAL; LIPIDS; MECHANISMS; EXTRACTS; AGENTS; PLANTS;

D O I：

10.1590/0001-3765201720160908

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86- 9.42 mu g/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15.6500 mu g/mL. Sunflower FAMEs exhibited antifungal activity that extended also to other genera, with an MIC of 15.6 mu g/mL against Candida glabrata and C. krusei and 31.2 mu g/mL against C. parapsilosis. FAMEs exhibited a synergetic effect with itraconazole. The antifungal activity of the FAMEs against isolates of Paracoccidioides spp. is likely due to the presence of methyl linoleate, the major compound present in all three FAMEs. The results obtained indicate the potential of FAMEs as sources for antifungal and antioxidant activity.

引用

页码：1671 / 1681

页数：11

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