Analysis of albendazole metabolites by electrospray LC-MS/MS as a probe to elucidate electro-oxidation mechanism of albendazole

被引：13
作者：
de Lima, RG
Bonato, PS
da Silva, RS
机构：
[1] USP, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, BR-14040901 Ribeirao Preto, Sao Paulo, Brazil
[2] USP, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, Sao Paulo, Brazil
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2003年 / 32卷 / 02期
基金：
巴西圣保罗研究基金会;
关键词：
albendazole; electrochemical oxidation; metabolites; LC-MS/MS;
D O I：
10.1016/S0731-7085(03)00128-6
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The electrochemical oxidation of albendazole was accomplished by controlled potential electrolyses technique. The oxidation was carried out in different pH solutions and yields the same products obtained by in vivo and in vitro metabolism, i.e. albendazole sulfoxide and albendazole sulfone. The identification of albendazole oxidation products was carried out by LC-MS/MS. (C) 2003 Elsevier Science B.V. All rights reserved.
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收藏
页码：337 / +
页数：8
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