Design and fabrication of chemically robust three-dimensional microfluidic valves

被引:31
作者
Maltezos, George
Garcia, Erika
Hanrahan, Grady [1 ]
Gomez, Frank A.
Vyawhare, Saurabh
van Dam, R. Michael
Chen, Yan
Scherer, Axel
机构
[1] CALTECH, Pasadena, CA 91125 USA
[2] Calif State Univ Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90032 USA
关键词
D O I
10.1039/b705031c
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
A current problem in microfluidics is that poly( dimethylsiloxane) ( PDMS), used to fabricate many microfluidic devices, is not compatible with most organic solvents. Fluorinated compounds are more chemically robust than PDMS but, historically, it has been nearly impossible to construct valves out of them by multilayer soft lithography ( MSL) due to the difficulty of bonding layers made of "non-stick'' fluoropolymers necessary to create traditional microfluidic valves. With our new three-dimensional ( 3D) valve design we can fabricate microfluidic devices from fluorinated compounds in a single monolithic layer that is resistant to most organic solvents with minimal swelling. This paper describes the design and development of 3D microfluidic valves by molding of a perfluoropolyether, termed Sifel, onto printed wax molds. The fabrication of Sifel-based microfluidic devices using this technique has great potential in chemical synthesis and analysis.
引用
收藏
页码:1209 / 1211
页数:3
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