Innovations in CRISPR technology

被引：17

作者：

Brooks, Alexandra K. ^{[1
]}

Gaj, Thomas ^{[1
]}

机构：

[1] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2018年 / 52卷

关键词：

HOMOLOGY-DIRECTED-REPAIR; MOUSE MODEL; DNA METHYLATION; GENE ACTIVATION; GENOMIC DNA; HUMAN-CELLS; BASE; CAS; SPECIFICITY; TRANSCRIPTION;

D O I：

10.1016/j.copbio.2018.03.007

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

CRISPR-Cas9 is a versatile tool for genome engineering that has revolutionized biotechnology and is poised to impact medicine. Recent advances in the identification of unique CRISPR systems, as well as the re-engineering of the Cas9 protein for expanded function, has enabled the diversification of the CRISPR genome engineering toolbox. In this review, we highlight these innovations and discuss how advances in CRISPR technology can lead to breakthroughs in the field of gene therapy.

引用

页码：95 / 101

页数：7

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