Plasma Neurofilament Light Chain Predicts Cognitive Progression in Prodromal and Clinical Dementia with Lewy Bodies

被引：29

作者：

Pilotto, Andrea ^{[1
,2
]}

Imarisio, Alberto ^{[1
]}

Carrarini, Claudia ^{[3
]}

Russo, Mirella ^{[3
]}

Masciocchi, Stefano ^{[1
]}

Gipponi, Stefano ^{[1
]}

Cottini, Elisabetta ^{[1
]}

Aarsland, Dag ^{[4
,10
]}

Zetterberg, Henrik ^{[5
,6
,7
,8
]}

Ashton, Nicholas J. ^{[5
,9
,10
,11
,12
]}

Hye, Abdul ^{[10
,11
,12
]}

Bonanni, Laura ^{[3
]}

Padovani, Alessandro ^{[1
]}

机构：

[1] Univ Brescia, Dept Clin & Expt Sci, Neurol Unit, Pzale Spedali Civili 1, I-25123 Brescia, Italy

[2] Osped S Isidoro, FERB Onlus, Bergamo, Italy

[3] Univ G dAnnunzio, Dept Neurosci Imaging & Clin Sci, Chieti, Italy

[4] Stavanger Univ Hosp, Ctr Age Related Med, Stavanger, Norway

[5] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Gothenburg, Sweden

[6] Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden

[7] UCL Inst Neurol, Dept Neurodegenerat Dis, London, England

[8] UK Dementia Res Inst UCL, London, England

[9] Univ Gothenburg, Inst Neurosci & Physiol, Dept Psychiat & Neurochem, Sahlgrenska Acad,Wallenberg Ctr Mol & Translat Me, Gothenburg, Sweden

[10] Kings Coll London, Maurice Wohl Clin Neurosci Inst, Inst Psychiat Psychol & Neurosci, Dept Old Age Psychiat, London, England

[11] South London & Maudsley NHS Fdn, NIHR Biomed Res Ctr Mental Hlth, London, England

[12] South London & Maudsley NHS Fdn, Biomed Res Unit Dementia, London, England

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2021年 / 82卷 / 03期

关键词：

Biomarkers; cognitive progression; dementia with Lewy bodies; neurofilament light chain; CEREBROSPINAL-FLUID; DIAGNOSIS; BIOMARKER; DECLINE;

D O I：

10.3233/JAD-210342

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Plasma neurofilament light chain (NfL) is a marker of neuronal damage in different neurological disorders and might predict disease progression in dementia with Lewy bodies (DLB). The study enrolled 45 controls and 44 DLB patients (including 17 prodromal cases) who underwent an extensive assessment at baseline and at 2 years follow-up. At baseline, plasma NfL levels were higher in both probable DLB and prodromal cases compared to controls. Plasma NfL emerged as the best predictor of cognitive decline compared to age, sex, and baseline severity variables. The study supports the role of plasma NfL as a useful prognostic biomarker from the early stages of DLB.

引用

页码：913 / 919

页数：7

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