Inhalation of fine particulate matter during pregnancy increased IL-4 cytokine levels in the fetal portion of the placenta

被引：80

作者：

de Melo, Juliana Oliveira ^{[1
]}

Soto, Sonia Fatima ^{[1
]}

Katayama, Isis Akemi ^{[1
]}

Wenceslau, Camilla Ferreira ^{[1
]}

Pires, Amanda Gonalves ^{[2
]}

Veras, Mariana Matera ^{[3
]}

Furukawa, Luzia N. S. ^{[1
]}

de Castro, Isac ^{[1
]}

Nascimento Saldiva, Paulo Hilario ^{[3
]}

Heimann, Joel Claudio ^{[1
]}

机构：

[1] Univ Sao Paulo, Lab Renal Physiopathol, Sch Med, Sao Paulo, Brazil

[2] Dept Internal Med, Lab Cellular Genet & Mol Nephrol, Sao Paulo, Brazil

[3] Dept Pathol, Lab Expt Air Pollut, Sao Paulo, Brazil

来源：

TOXICOLOGY LETTERS | 2015年 / 232卷 / 02期

基金：

巴西圣保罗研究基金会;

关键词：

Air pollution; Decidua; Inflammation; Placenta and pregnancy; AIR-POLLUTION EXPOSURE; PRETERM BIRTH; ENDOTHELIAL DYSFUNCTION; MATERNAL EXPOSURE; INFLAMMATION; MARKERS; POLLUTANTS; OUTCOMES; GROWTH;

D O I：

10.1016/j.toxlet.2014.12.001

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

This study aimed to verify the development of placental and systemic inflammation in rats exposed to fine particulate matter before or during pregnancy. Wistar rats were exposed to filtered air ( control) or to a load of 600 mu g/m(3) of fine particles in the air. The gene expression of IL-1 beta, IL-4, IL-6, IL-10, INF-gamma, TNF-alpha and Toll-like receptor 4 in the placenta was evaluated. The serum and placental concentrations of IL-1 beta, IL-4, IL-6, IL-10, INF-gamma and TNF-alpha were measured. The total and differential blood leukocyte and blood platelet count was assessed. Compared to control animals, IL-4 content was elevated in the fetal portion of the placenta in rats exposed to air pollution before and during pregnancy. Increased IL-4 suggests that a placental inflammatory reaction may have occurred in response to exposure to fine particulate matter and that this cytokine was responsible, among possibly others factors, for resolution of the inflammatory reaction. (c) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：475 / 480

页数：6

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