Y chromosome evidence for a founder effect in Ashkenazi Jews

被引：16
作者：
Nebel, A
Filon, D
Faerman, M
Soodyall, H
Oppenheim, A
机构：
[1] Hebrew Univ Jerusalem, Hadassah Sch Dent Med, Fac Med Dent,Lab Biol Anthropol & Ancient DNA, Dept Biol Anthropol & Ancient DNA, IL-91120 Jerusalem, Israel
[2] Natl Hlth Lab Serv, Sch Pathol, Div Human Genet, MRC NHLS Wits Human Gen Divers & Dis Res Unit, Johannesburg, South Africa
[3] Univ Witwatersrand, Johannesburg, South Africa
[4] Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Hematol, IL-91010 Jerusalem, Israel
[5] Hadassah Univ Hosp, IL-91120 Jerusalem, Israel
来源：
EUROPEAN JOURNAL OF HUMAN GENETICS | 2005年 / 13卷 / 03期
关键词：
Y chromosome haplotypes; Ashkenazi Jews; founder effect;
D O I：
10.1038/sj.ejhg.5201319
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent genetic studies, based on Y chromosome polymorphic markers, showed that Ashkenazi Jews are more closely related to other Jewish and Middle Eastern groups than to their host populations in Europe. However, Ashkenazim have an elevated frequency of R-M17, the dominant Y chromosome haplogroup in Eastern Europeans, suggesting possible gene flow. In the present study of 495 Y chromosomes of Ashkenazim, 57 (11.5%) were found to belong to R-M17. Detailed analyses of haplotype structure, diversity and geographic distribution suggest a founder effect for this haplogroup, introduced at an early stage into the evolving Ashkenazi community in Europe. R-M17 chromosomes in Ashkenazim may represent vestiges of the mysterious Khazars.
引用
收藏
页码：388 / 391
页数：4
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