Future cancer research priorities in the USA: a Lancet Oncology Commission

被引：157

作者：

Jaffee, Elizabeth M. ^{[1
]}

Dang, Chi Van ^{[2
,3
]}

Agus, David B. ^{[4
]}

Alexander, Brian M. ^{[5
]}

Anderson, Kenneth C. ^{[5
]}

Ashworth, Alan ^{[7
]}

Barker, Anna D. ^{[8
]}

Bastani, Roshan ^{[9
,10
]}

Bhatia, Sangeeta ^{[11
]}

Bluestone, Jeffrey A. ^{[7
,12
]}

Brawley, Otis ^{[13
]}

Butte, Atul J. ^{[7
]}

Coit, Daniel G. ^{[14
]}

Davidson, Nancy E. ^{[18
,19
]}

Davis, Mark ^{[20
]}

DePinho, Ronald A. ^{[21
]}

Diasio, Robert B. ^{[22
]}

Draetta, Giulio ^{[21
]}

Frazier, A. Lindsay ^{[5
]}

Futreal, Andrew ^{[21
]}

Gambhir, Sam S. ^{[23
]}

Ganz, Patricia A. ^{[9
,10
]}

Garraway, Levi ^{[5
,24
,25
]}

Gerson, Stanton ^{[26
]}

Gupta, Sumit ^{[27
,28
]}

Heath, James ^{[20
]}

Hoffman, Ruth I. ^{[29
]}

Hudis, Cliff ^{[15
]}

Hughes-Halbert, Chanita ^{[30
,31
]}

Ibrahim, Ramy ^{[12
]}

Jadvar, Hossein ^{[32
]}

Kavanagh, Brian ^{[33
]}

Kittles, Rick ^{[34
,35
]}

Quynh-Thu Le ^{[23
]}

Lippman, Scott M. ^{[36
]}

Mankoff, David ^{[37
,38
]}

Mardis, Elaine R. ^{[39
,40
]}

Mayer, Deborah K. ^{[42
]}

McMasters, Kelly ^{[43
]}

Meropol, Neal J. ^{[44
]}

Mitchell, Beverly ^{[23
]}

Naredi, Peter ^{[45
]}

Ornish, Dean ^{[7
]}

Pawlik, Timothy M. ^{[41
]}

Peppercorn, Jeffrey ^{[6
]}

Pomper, Martin G. ^{[1
]}

Raghavan, Derek ^{[46
]}

Ritchie, Christine ^{[7
]}

Schwarz, Sally W. ^{[47
]}

Sullivan, Richard ^{[48
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Baltimore, MD 21287 USA

[2] Ludwig Inst Canc Res, New York, NY 10017 USA

[3] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA

[4] Univ Southern Calif, Beverly Hills, CA USA

[5] Harvard Med Sch, Dana Farber Canc Inst, Boston, MA USA

[6] Harvard Med Sch, Massachusetts Gen Hosp, Boston, MA USA

[7] Univ Calif San Francisco, San Francisco, CA 94143 USA

[8] Arizona State Univ, Tempe, AZ USA

[9] Univ Calif Los Angeles, Fielding Sch Publ Hlth, Los Angeles, CA USA

[10] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, Los Angeles, CA 90024 USA

[11] MIT, Koch Inst Integrat Canc Res, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[12] Parker Inst Canc Immunotherapy, San Francisco, CA USA

[13] Amer Canc Soc, Atlanta, GA 30329 USA

[14] Mem Sloan Kettering Canc Ctr, Dept Surg, 1275 York Ave, New York, NY 10021 USA

[15] Mem Sloan Kettering Canc Ctr, Breast Canc Med Serv, 1275 York Ave, New York, NY 10021 USA

[16] Mem Sloan Kettering Canc Ctr, Ludwig Ctr Canc Immunotherapy, Dept Med, 1275 York Ave, New York, NY 10021 USA

[17] Parker Inst Canc Immunotherapy, San Francisco, CA USA

[18] Fred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA

[19] Univ Washington, Seattle, WA 98195 USA

[20] CALTECH, Pasadena, CA 91125 USA

[21] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[22] Mayo Clin, Ctr Canc, Rochester, MN USA

[23] Stanford Univ, Stanford, CA 94305 USA

[24] Broad Inst, Cambridge, MA USA

[25] Eli Lilly & Co, Boston, MA USA

[26] Case Comprehens Canc Ctr, Cleveland, OH USA

[27] Univ Toronto, Fac Med, Hosp Sick Children, Div Haematol Oncol, Toronto, ON, Canada

[28] Univ Toronto, IHPME, Toronto, ON, Canada

[29] Amer Childhood Canc Org, Beltsville, MD USA

[30] Med Univ South Carolina, Charleston, SC USA

[31] Hollings Canc Ctr, Charleston, SC USA

[32] Univ Southern Calif, Keck Sch Med, Los Angeles, CA USA

[33] Univ Colorado, Dept Radiat Oncol, Denver, CO 80202 USA

[34] Univ Arizona, Coll Med, Tucson, AZ USA

[35] Univ Arizona, Univ Arizona Canc Ctr, Tucson, AZ USA

[36] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

[37] Univ Penn, Perelman Sch Med, Dept Radiol, Philadelphia, PA 19104 USA

[38] Univ Penn, Perelman Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[39] Childrens Hosp Columbus, Inst Genom Med Nationwide, Columbus, OH USA

[40] Ohio State Univ, Coll Med, Columbus, OH 43210 USA

[41] Ohio State Univ, Dept Surg, Wexner Med Ctr, Columbus, OH 43210 USA

[42] Univ N Carolina, Lineberger Canc Ctr, Chapel Hill, NC USA

[43] Univ Louisville, Sch Med, Hiram C Polk Jr MD Dept Surg, Louisville, KY 40292 USA

[44] Flatiron Hlth, New York, NY USA

[45] Univ Gothenburg, Sahlgrenska Acad, Inst Clin Sci, Dept Surg, Gothenburg, Sweden

[46] Carolinas HealthCare, Levine Canc Inst, Charlotte, NC USA

[47] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO USA

[48] Kings Coll London, London, England

[49] Geisel Sch Med Dartmouth, Dept Surg, Lebanon, NH USA

来源：

LANCET ONCOLOGY | 2017年 / 18卷 / 11期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; BODY RADIATION-THERAPY; LIFE-STYLE CHANGES; INDUCED PERIPHERAL NEUROPATHY; CIRCULATING TUMOR-CELLS; QUALITY-OF-LIFE; SUSCEPTIBILITY GENE-MUTATIONS; TARGETED RADIONUCLIDE THERAPY; ACUTE LYMPHOBLASTIC-LEUKEMIA; HER2-POSITIVE BREAST-CANCER;

D O I：

10.1016/S1470-2045(17)30698-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We are in the midst of a technological revolution that is providing new insights into human biology and cancer. In this era of big data, we are amassing large amounts of information that is transforming how we approach cancer treatment and prevention. Enactment of the Cancer Moonshot within the 21st Century Cures Act in the USA arrived at a propitious moment in the advancement of knowledge, providing nearly US$ 2 billion of funding for cancer research and precision medicine. In 2016, the Blue Ribbon Panel (BRP) set out a roadmap of recommendations designed to exploit new advances in cancer diagnosis, prevention, and treatment. Those recommendations provided a high-level view of how to accelerate the conversion of new scientific discoveries into effective treatments and prevention for cancer. The US National Cancer Institute is already implementing some of those recommendations. As experts in the priority areas identified by the BRP, we bolster those recommendations to implement this important scientific roadmap. In this Commission, we examine the BRP recommendations in greater detail and expand the discussion to include additional priority areas, including surgical oncology, radiation oncology, imaging, health systems and health disparities, regulation and financing, population science, and oncopolicy. We prioritise areas of research in the USA that we believe would accelerate efforts to benefit patients with cancer. Finally, we hope the recommendations in this report will facilitate new international collaborations to further enhance global efforts in cancer control.

引用

页码：E653 / E706

页数：54

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