Design, synthesis, and biological evaluation of a novel class of fluorescein-based N-glycosylamines

被引：18

作者：

Rajasekar, Mani ^{[1
]}

Khan, Sulaiman Mahaboob ^{[2
]}

Devaraj, Sivasithamparam Niranjali ^{[2
]}

Das, Thangamuthu Mohan ^{[1
]}

机构：

[1] Univ Madras, Dept Organ Chem, Madras 600025, Tamil Nadu, India

[2] Univ Madras, Dept Biochem, Madras 600025, Tamil Nadu, India

来源：

CARBOHYDRATE RESEARCH | 2011年 / 346卷 / 13期

关键词：

Fluorescein derivatives; N-Glycosylamines; Organogelators; Morphological studies; Cell imaging studies; NITRIC-OXIDE DETECTION; COPPER-COMPLEXES; IN-VITRO; DERIVATIVES; PLATFORM; LIGANDS; CELL;

D O I：

10.1016/j.carres.2011.06.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of fluorescein-based N-glycosylamines was synthesized from the corresponding fluorescein amine and a partially protected D-glucose. The physiochemical investigation of these compounds by spectral and morphological studies reveals their gelation potential. The exclusive localization of fluorescence in the cytoplasm through cell imaging studies reveals the anti-cancer potentials of N-glycosylamines. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1776 / 1785

页数：10

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