Silencing preBotzinger Complex somatostatin-expressing neurons induces persistent apnea in awake rat

被引：239

作者：

Tan, Wenbin ^{[1
]}

Janczewski, Wiktor A. ^{[1
]}

Yang, Paul ^{[1
]}

Shao, Xuesi M. ^{[1
]}

Callaway, Edward M. ^{[2
]}

Feldman, Jack L. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurobiol, Los Angeles, CA 90095 USA

[2] Salk Inst Biol Studies, Syst Neurobiol Lab, La Jolla, CA 92037 USA

来源：

NATURE NEUROSCIENCE | 2008年 / 11卷 / 05期

关键词：

D O I：

10.1038/nn.2104

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Delineating neurons that underlie complex behaviors is of fundamental interest. Using adeno-associated virus 2, we expressed the Drosophila allatostatin receptor in somatostatin (Sst)-expressing neurons in the preBotzinger Complex (preBotC). Rapid silencing of these neurons in awake rats induced a persistent apnea without any respiratory movements to rescue their breathing. We hypothesize that breathing requires preBotC Sst neurons and that their sudden depression can lead to serious, even fatal, respiratory failure.

引用

页码：538 / 540

页数：3

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