Synthesis of Isochromene and Related Derivatives by Rhodium-Catalyzed Oxidative Coupling of Benzyl and Allyl Alcohols with Alkynes

被引：83
作者：
Morimoto, Keisuke [1 ]
Hirano, Koji [1 ]
Satoh, Tetsuya [1 ]
Miura, Masahiro [1 ]
机构：
[1] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 22期
关键词：
C-H BOND; CARBON-HYDROGEN BONDS; INTERNAL ALKYNES; ACTIVATION; FUNCTIONALIZATION; CLEAVAGE; HETEROCYCLES; ARYLATION; ALKENES; ROUTE;
D O I：
10.1021/jo201923d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The straightforward synthesis of isochromene derivatives and related cyclic ethers is achieved by the rhodium-catalyzed oxidative coupling of alpha,alpha-disubstituted benzyl and allyl alcohols with alkynes. The hydroxy groups effectively act as the key function for the regioselective C-H bond cleavage.
引用
收藏
页码：9548 / 9551
页数：4
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