Synthesis of Isochromene and Related Derivatives by Rhodium-Catalyzed Oxidative Coupling of Benzyl and Allyl Alcohols with Alkynes

被引：83

作者：

Morimoto, Keisuke ^{[1
]}

Hirano, Koji ^{[1
]}

Satoh, Tetsuya ^{[1
]}

Miura, Masahiro ^{[1
]}

机构：

[1] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2011年 / 76卷 / 22期

关键词：

C-H BOND; CARBON-HYDROGEN BONDS; INTERNAL ALKYNES; ACTIVATION; FUNCTIONALIZATION; CLEAVAGE; HETEROCYCLES; ARYLATION; ALKENES; ROUTE;

D O I：

10.1021/jo201923d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The straightforward synthesis of isochromene derivatives and related cyclic ethers is achieved by the rhodium-catalyzed oxidative coupling of alpha,alpha-disubstituted benzyl and allyl alcohols with alkynes. The hydroxy groups effectively act as the key function for the regioselective C-H bond cleavage.

引用

页码：9548 / 9551

页数：4

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