Notch regulation of lymphocyte development and function

被引：422

作者：

Radtke, F ^{[1
]}

Wilson, A ^{[1
]}

Mancini, SJC ^{[1
]}

MacDonald, HR ^{[1
]}

机构：

[1] Univ Lausanne, Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Epalinges, Switzerland

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 03期

关键词：

D O I：

10.1038/ni1045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal development. Mammals have four Notch receptors that bind five different ligands. The function of Notch signaling during lymphopoiesis and T cell neoplasia, based on gain-of-function and conditional loss-of-function approaches for the Notch1 receptor, indicates Notch1 is essential in T cell lineage commitment. Recent studies have addressed the involvement of other Notch receptors and ligands as well as their downstream targets, demonstrating additional functions of Notch signaling in embryonic hematopoiesis, intrathymic T cell development, B cell development and peripheral T cell function.

引用

页码：247 / 253

页数：7

共 114 条

[31] Entry into the thymic microenvironment triggers notch activation in the earliest migrant T cell progenitors [J].

Harman, BC ;

Jenkinson, EJ ;

Anderson, G .

JOURNAL OF IMMUNOLOGY, 2003, 170 (03) :1299-1303

[32] Modulated expression of NOTCH1 during thymocyte development [J].

Hasserjian, RP ;

Aster, JC ;

Davi, F ;

Weinberg, DS ;

Sklar, J .

BLOOD, 1996, 88 (03) :970-976

[33] Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4+ T cells [J].

Hoyne, GF ;

Le Roux, I ;

Corsin-Jimenez, M ;

Tan, K ;

Dunne, J ;

Forsyth, LMG ;

Dallman, MJ ;

Owen, MJ ;

Ish-Horowicz, D ;

Lamb, JR .

INTERNATIONAL IMMUNOLOGY, 2000, 12 (02) :177-185

[34] Active form of notch members can enforce T lymphopoiesis on lymphoid progenitors in the monolayer culture specific for B cell development [J].

Hozumi, K ;

Abe, N ;

Chiba, S ;

Hirai, H ;

Habu, S .

JOURNAL OF IMMUNOLOGY, 2003, 170 (10) :4973-4979

[35] CIR, a corepressor linking the DNA binding factor CBF1 to the histone deacetylase complex [J].

Hsieh, JJD ;

Zhou, SF ;

Chen, L ;

Young, DB ;

Hayward, SD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (01) :23-28

[36] F3/contactin acts as a functional ligand for notch during oligodendrocyte maturation [J].

Hu, QD ;

Ang, BT ;

Karsak, M ;

Hu, WP ;

Cui, XY ;

Duka, T ;

Takeda, Y ;

Chia, W ;

Sankar, N ;

Ng, YK ;

Ling, EA ;

Maciag, T ;

Small, D ;

Trifonova, R ;

Kopan, R ;

Okano, H ;

Nakafuku, M ;

Chiba, S ;

Hirai, H ;

Aster, JC ;

Schachner, M ;

Pallen, CJ ;

Watanabe, K ;

Xiao, ZC .

CELL, 2003, 115 (02) :163-175

[37] Surface expression of Notch1 on thymocytes: Correlation with the double-negative to double-positive transition [J].

Huang, EY ;

Gallegos, AM ;

Richards, SM ;

Lehar, SM ;

Bevan, MJ .

JOURNAL OF IMMUNOLOGY, 2003, 171 (05) :2296-2304

[38] Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia [J].

Hubmann, R ;

Schwarzmeier, JD ;

Shehata, M ;

Hilgarth, M ;

Duechler, M ;

Dettke, M ;

Berger, R .

BLOOD, 2002, 99 (10) :3742-3747

[39] HES and HERP families: Multiple effectors of the Notch signaling pathway [J].

Iso, T ;

Kedes, L ;

Hamamori, Y .

JOURNAL OF CELLULAR PHYSIOLOGY, 2003, 194 (03) :237-255

[40] Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1 [J].

Izon, DJ ;

Aster, JC ;

He, YP ;

Weng, A ;

Karnell, FG ;

Patriub, V ;

Xu, LW ;

Bakkour, S ;

Rodriguez, C ;

Allman, D ;

Pear, WS .

IMMUNITY, 2002, 16 (02) :231-243

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