Notch regulation of lymphocyte development and function

被引：422

作者：

Radtke, F ^{[1
]}

Wilson, A ^{[1
]}

Mancini, SJC ^{[1
]}

MacDonald, HR ^{[1
]}

机构：

[1] Univ Lausanne, Ludwig Inst Canc Res, Lausanne Branch, CH-1066 Epalinges, Switzerland

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 03期

关键词：

D O I：

10.1038/ni1045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Notch proteins regulate a broad spectrum of cell fate decisions and differentiation processes during fetal and postnatal development. Mammals have four Notch receptors that bind five different ligands. The function of Notch signaling during lymphopoiesis and T cell neoplasia, based on gain-of-function and conditional loss-of-function approaches for the Notch1 receptor, indicates Notch1 is essential in T cell lineage commitment. Recent studies have addressed the involvement of other Notch receptors and ligands as well as their downstream targets, demonstrating additional functions of Notch signaling in embryonic hematopoiesis, intrathymic T cell development, B cell development and peripheral T cell function.

引用

页码：247 / 253

页数：7

共 114 条

[1] Notch signaling augments T cell responsiveness by enhancing CD25 expression [J].

Adler, SH ;

Chiffoleau, E ;

Xu, LW ;

Dalton, NM ;

Burg, JM ;

Wells, AD ;

Wolfe, MS ;

Turka, LA ;

Pear, WS .

JOURNAL OF IMMUNOLOGY, 2003, 171 (06) :2896-2903

[2] Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells [J].

Allman, D ;

Karnell, FG ;

Punt, JA ;

Bakkour, S ;

Xu, LW ;

Myung, P ;

Koretzky, GA ;

Pui, JC ;

Aster, JC ;

Pear, WS .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (01) :99-106

[3] Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes [J].

Anastasi, E ;

Campese, AF ;

Bellavia, D ;

Bulotta, A ;

Balestri, A ;

Pascucci, M ;

Checquolo, S ;

Gradini, R ;

Lendahl, U ;

Frati, L ;

Gulino, A ;

Di Mario, U ;

Screpanti, I .

JOURNAL OF IMMUNOLOGY, 2003, 171 (09) :4504-4511

[4]

Anderson G, 2001, EUR J IMMUNOL, V31, P3349, DOI 10.1002/1521-4141(200111)31:11<3349::AID-IMMU3349>3.0.CO

[5]

2-S

[6] Notch signaling: Cell fate control and signal integration in development [J].

Artavanis-Tsakonas, S ;

Rand, MD ;

Lake, RJ .

SCIENCE, 1999, 284 (5415) :770-776

[7] Constitutive activation of NF-κB and T-cell leukemia/lymphoma in Notch3 transgenic mice [J].

Bellavia, D ;

Campese, AF ;

Alesse, E ;

Vacca, A ;

Felli, MP ;

Balestri, A ;

Stoppacciaro, A ;

Tiveron, C ;

Tatangelo, L ;

Giovarelli, M ;

Gaetano, C ;

Ruco, L ;

Hoffman, ES ;

Hayday, AC ;

Lendahl, U ;

Frati, L ;

Gulino, A ;

Screpanti, I .

EMBO JOURNAL, 2000, 19 (13) :3337-3348

[8] Combined expression of pTα and Notch3 in T cell leukemia identifies the requirement of preTCR for leukemogenesis [J].

Bellavia, D ;

Campese, AF ;

Checquolo, S ;

Balestri, A ;

Biondi, A ;

Cazzaniga, G ;

Lendahl, U ;

Fehling, HJ ;

Hayday, AC ;

Frati, L ;

von Boehmer, H ;

Gulino, A ;

Screpanti, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3788-3793

[9] Perturbation of lkaros isoform selection by MLV integration is a cooperative event in NotchIC-induced T cell leukemogenesis [J].

Beverly, LJ ;

Capobianco, AJ .

CANCER CELL, 2003, 3 (06) :551-564

[10] Osteoblastic cells regulate the haematopoietic stem cell niche [J].

Calvi, LM ;

Adams, GB ;

Weibrecht, KW ;

Weber, JM ;

Olson, DP ;

Knight, MC ;

Martin, RP ;

Schipani, E ;

Divieti, P ;

Bringhurst, FR ;

Milner, LA ;

Kronenberg, HM ;

Scadden, DT .

NATURE, 2003, 425 (6960) :841-846

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