The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study

被引:19
作者
Gigic, Biljana [1 ,2 ,3 ]
Nattenmueller, Johanna [4 ]
Schneider, Martin [1 ]
Kulu, Yakup [1 ]
Syrjala, Karen L. [5 ]
Bohm, Jurgen [6 ]
Schrotz-King, Petra [2 ,3 ]
Brenner, Hermann [2 ,3 ,7 ,8 ]
Colditz, Graham A. [9 ,10 ]
Figueiredo, Jane C. [11 ]
Grady, William M. [5 ,12 ,13 ]
Li, Christopher, I [12 ]
Shibata, David [14 ]
Siegel, Erin M. [15 ]
Toriola, Adetunji T. [9 ,10 ]
Kauczor, Hans-Ulrich [4 ]
Ulrich, Alexis [1 ]
Ulrich, Cornelia M. [6 ,16 ]
机构
[1] Heidelberg Univ Hosp, Dept Gen Visceral & Transplantat Surg, D-69120 Heidelberg, Germany
[2] Natl Ctr Tumor Dis, Div Prevent Oncol, D-69120 Heidelberg, Germany
[3] German Canc Res Ctr, D-69120 Heidelberg, Germany
[4] Heidelberg Univ Hosp, Dept Diagnost & Intervent Radiol, D-69120 Heidelberg, Germany
[5] Fred Hutchinson Canc Res Ctr, Clin Res Div, Seattle, WA 98109 USA
[6] Huntsman Canc Inst, Populat Sci, Salt Lake City, UT 84112 USA
[7] German Canc Res Ctr, Div Clin Epidemiol & Aging Res, D-69120 Heidelberg, Germany
[8] German Canc Res Ctr, German Canc Consortium DKTK, D-69120 Heidelberg, Germany
[9] Washington Univ, Dept Surg, Div Publ Hlth Sci, Sch Med, St Louis, MO 63110 USA
[10] Siteman Canc Ctr, St Louis, MO 63110 USA
[11] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Dept Med, Los Angeles, CA 90048 USA
[12] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA 98109 USA
[13] Univ Washington, Dept Med, Sch Med, Seattle, WA 98195 USA
[14] Univ Tennessee, Dept Surg, Hlth Sci Ctr, Memphis, TN 38163 USA
[15] H Lee Moffitt Canc Ctr & Res Inst, Canc Epidemiol Program, Tampa, FL 33612 USA
[16] Univ Utah, Dept Populat Hlth Sci, Salt Lake City, UT 84112 USA
关键词
visceral fat area; subcutaneous fat area; skeletal muscle mass; CT-quantified body composition; health-related quality of life; colorectal cancer; prospective data; VISCERAL OBESITY; EUROPEAN-ORGANIZATION; SURGICAL OUTCOMES; PROGNOSTIC-FACTOR; MASS INDEX; POPULATION; SARCOPENIA; DIAGNOSIS; DISEASE; COMPLICATIONS;
D O I
10.3390/nu12051247
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle mass. Computed tomography (CT)-defined body composition more accurately reflects different types of tissue and their associations with health-related quality of life (HRQoL) during the first year of disease, but this has not been investigated yet. We studied the role of visceral and subcutaneous fat area (VFA and SFA) and skeletal muscle mass (SMM) on longitudinally assessed HRQoL in CRC patients. Methods: A total of 138 newly diagnosed CRC patients underwent CT scans at diagnosis and completed questionnaires prior to and six and twelve months post-surgery. We investigated the associations of VFA, SFA, and SMM with HRQoL at multiple time points. Results: A higher VFA was associated with increased pain six and twelve months post-surgery (beta = 0.06,p= 0.04 and beta = 0.07,p= 0.01) and with worse social functioning six months post-surgery (beta = -0.08,p= 0.01). Higher SMM was associated with increased pain twelve months post-surgery (beta = 1.03,p< 0.01). Conclusions: CT-quantified body composition is associated with HRQoL scales post-surgery. Intervention strategies targeting a reduction in VFA and maintaining SMM might improve HRQoL in CRC patients during the first year post-surgery.
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页数:14
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