Regulation of angiotensin II type 1 (AT1) receptor function

被引:84
|
作者
Thomas, WG [1 ]
机构
[1] Baker Med Res Inst, Mol Endocrinol Lab, Melbourne, Vic 8008, Australia
关键词
D O I
10.1016/S0167-0115(98)00140-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The type 1 angiotensin receptor (AT(1)) mediates the important biological actions of the peptide hormone, angiotensin II (AngII), by activating an array of intracellular signaling pathways. The unique temporal arrangement and duration of AngII-stimulated signals suggests a hierarchy of post-AT(1) receptor binding events that permits activation of selective effector pathways. Moreover, it predicts that the coupling of AT(1) receptors is tightly regulated, allowing cells to differentiate acute responses from those requiring longer periods of stimulation. Recent studies have concentrated on delineating the molecular processes involved in modulating AT(1) receptor activity. In addition to AT(1) receptor modification (phosphorylation), trafficking (internalization and degradation) and interaction with regulatory intracellular proteins, other processes may include receptor dimerization, cross-regulation by other receptor systems, and receptor isomerization between activated and non-activated forms. This review focuses on recent advances in this area of research, highlighting directions for future investigation. (C) 1999 Elsevier Science B.V. All rights reserved.
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页码:9 / 23
页数:15
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