Metabolic heterogeneity and adaptability in brain tumors

被引：48

作者：

Badr, Christian E. ^{[1
,2
]}

Silver, Daniel J. ^{[3
,4
]}

Siebzehnrubl, Florian A. ^{[5
]}

Deleyrolle, Loic P. ^{[6
]}

机构：

[1] Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02114 USA

[2] Harvard Med Sch, Neurosci Program, Boston, MA 02115 USA

[3] Cleveland Clin Fdn, Dept Cardiovasc & Metab Sci, Lerner Res Inst, 9500 Euclid Ave, Cleveland, OH 44195 USA

[4] Case Western Reserve Univ, Case Comprehens Canc Ctr, Cleveland, OH 44106 USA

[5] Cardiff Univ, European Canc Stem Cell Res Inst, Sch Biosci, Cardiff CF24 4HQ, Wales

[6] Univ Florida, Lillian S Wells Dept Neurosurg, Preston A Wells Jr Ctr Brain Tumor Therapy, Gainesville, FL 32611 USA

来源：

CELLULAR AND MOLECULAR LIFE SCIENCES | 2020年 / 77卷 / 24期

基金：

英国医学研究理事会;

关键词：

Glioma; Tumor microenvironment (TME); Metabolism; Cell communication; Tumor initiating cells; Slow-cycling cells; Immune cells; FATTY-ACID OXIDATION; CANCER STEM-CELLS; GLUCOSE-TRANSPORTER GLUT1; HUMAN GLIOBLASTOMA; SUPPRESSOR-CELLS; INITIATING CELLS; DENDRITIC CELLS; SELF-RENEWAL; INTRATUMOR HETEROGENEITY; SYNTHETIC LETHALITY;

D O I：

10.1007/s00018-020-03569-w

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The metabolic complexity and flexibility commonly observed in brain tumors, especially glioblastoma, is fundamental for their development and progression. The ability of tumor cells to modify their genetic landscape and adapt metabolically, subverts therapeutic efficacy, and inevitably instigates therapeutic resistance. To overcome these challenges and develop effective therapeutic strategies targeting essential metabolic processes, it is necessary to identify the mechanisms underlying heterogeneity and define metabolic preferences and liabilities of malignant cells. In this review, we will discuss metabolic diversity in brain cancer and highlight the role of cancer stem cells in regulating metabolic heterogeneity. We will also highlight potential therapeutic modalities targeting metabolic vulnerabilities and examine how intercellular metabolic signaling can shape the tumor microenvironment.

引用

页码：5101 / 5119

页数：19

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