Achalasia

被引:22
作者
Beck, William C. [1 ]
Sharp, Kenneth W. [1 ]
机构
[1] Vanderbilt Univ, Med Ctr, Dept Surg, Div Gen Surg, Nashville, TN 37232 USA
关键词
Achalasia; Esophagomyotomy; Lower esophageal sphincter; Esophageal motility; LAPAROSCOPIC HELLER MYOTOMY; RANDOMIZED CONTROLLED-TRIAL; INTRASPHINCTERIC BOTULINUM-TOXIN; LONG-TERM TREATMENT; ESOPHAGEAL ACHALASIA; DOUBLE-BLIND; PNEUMATIC DILATATION; DOR FUNDOPLICATION; BALLOON DILATATION; INJECTION;
D O I
10.1016/j.suc.2011.06.005
中图分类号
R61 [外科手术学];
学科分类号
摘要
This article reviews the diagnosis and treatment of achalasia, a rare esophageal motility disorder characterized by absent peristalsis and failure of the lower esophageal sphincter (LES) to relax. Various treatment options including management with sublingual nitrates or calcium channel blockers, injection of the LES with botulism toxin, pneumatic dilation of the LES, and pneumatic dilation are discussed. Laparoscopic Heller myotomy is minimally invasive with incumbent low morbidity and mortality rates, and combined with a partial fundoplication is a durable, safe, and effective treatment option for patients with achalasia.
引用
收藏
页码:1031 / +
页数:8
相关论文
共 46 条
  • [1] Predictors for outcome of failure of balloon dilatation in patients with achalasia
    Alderliesten, J.
    Conchillo, J. M.
    Leeuwenburgh, I.
    Steyerberg, E. W.
    Kuipers, E. J.
    [J]. GUT, 2011, 60 (01) : 10 - 16
  • [2] Annese V, 1999, ALIMENT PHARM THERAP, V13, P1347
  • [3] Botulinum toxin in long-term therapy for achalasia
    Annese, V
    D'Onofrio, V
    Andriulli, A
    [J]. ANNALS OF INTERNAL MEDICINE, 1998, 128 (08) : 696 - 696
  • [4] Annese V, 1998, MUSCLE NERVE, V21, P1540, DOI 10.1002/(SICI)1097-4598(199811)21:11<1540::AID-MUS27>3.0.CO
  • [5] 2-2
  • [6] A multicentre randomised study of intrasphincteric botulinum toxin in patients with oesophageal achalasia
    Annese, V
    Bassotti, G
    Coccia, G
    Dinelli, M
    D'Onofrio, V
    Gatto, G
    Leandro, G
    Repici, A
    Testoni, PA
    Andriulli, A
    [J]. GUT, 2000, 46 (05) : 597 - 600
  • [7] HISTORY OF SURGERY OF THE ESOPHAGUS
    BREWER, LA
    [J]. AMERICAN JOURNAL OF SURGERY, 1980, 139 (06) : 730 - 743
  • [8] Achalasia: Outcome of patients treated with intrasphincteric injection of botulinum toxin
    Cuilliere, C
    Ducrotte, P
    Zerbib, F
    Metman, EH
    deLooze, D
    Guillemot, F
    Hudziak, H
    Lamouliatte, H
    Grimaud, JC
    Ropert, A
    Dapoigny, M
    Bost, R
    Lemann, M
    Bigard, MA
    Denis, P
    Auget, JL
    Galmiche, JP
    desVarannes, SB
    [J]. GUT, 1997, 41 (01) : 87 - 92
  • [9] PREDICTORS OF OUTCOME IN PATIENTS WITH ACHALASIA TREATED BY PNEUMATIC DILATION
    ECKARDT, VF
    AIGNHERR, C
    BERNHARD, G
    [J]. GASTROENTEROLOGY, 1992, 103 (06) : 1732 - 1738
  • [10] Idiopathic (primary) achalasia
    Farrokhi, Farnoosh
    Vaezi, Michael F.
    [J]. ORPHANET JOURNAL OF RARE DISEASES, 2007, 2 (1)