The power and the promise of circRNAs for cancer precision medicine with functional diagnostics and prognostic prediction

被引：7

作者：

Ma, Yu-Shui ^{[1
,2
,3
,4
]}

Cao, Yong-Feng ^{[2
]}

Liu, Ji-Bin ^{[2
]}

Li, Wen ^{[1
]}

Deng, Jing ^{[1
]}

Yang, Xiao-Li ^{[4
]}

Xin, Rui ^{[4
]}

Shi, Yi ^{[1
,4
]}

Zhang, Dan-Dan ^{[4
]}

Lv, Zhong-Wei ^{[4
]}

Fu, Da ^{[1
,5
]}

机构：

[1] Cent South Univ Forestry & Technol, Coll Food Sci & Engn, Natl Engn Lab Deep Proc Rice & Byprod, Changsha 410004, Hunan, Peoples R China

[2] Affiliated Tumor Hosp Nantong Univ, Dept Tumor, Nantong 226300, Peoples R China

[3] Second Mil Med Univ, Natl Ctr Liver Canc, Eastern Hepatobiliary Surg Hosp Inst, Int Cooperat Lab Signal Transduct, Shanghai 200433, Peoples R China

[4] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Nucl Med, Shanghai 200072, Peoples R China

[5] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Inst Pancreat Dis, Shanghai 200025, Peoples R China

来源：

CARCINOGENESIS | 2021年 / 42卷 / 11期

基金：

中国国家自然科学基金;

关键词：

CIRCULATING TUMOR DNA; NONCODING RNAS; CELL-GROWTH; GLUCOSE-METABOLISM; POTENTIAL ROLES; BLADDER-CANCER; MECHANISMS; MIGRATION; BIOMARKER; PROTEIN;

D O I：

10.1093/carcin/bgab071

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Circular RNA (circRNA) is a large class of covalently closed circRNA. As a member of competitive endogenous RNA, it participates in the regulation of circRNA-miRNA-mRNA network and plays an important role in the regulation of physiology and pathology. CircRNA is produced by the reverse splicing of exon, intron or both, forming exon or intron circRNA. Studies have shown that circRNA is a ubiquitous molecule, which exceeds the linear mRNA distributed in human cells. Because of its covalent closed-loop structure, circRNA is resistant to RNase R, which is more stable than linear mRNA; circRNA is highly conserved in different species. It was found that circRNA competitively adsorbs miRNA, as a miRNA sponge, to involve in the expression regulation of a variety of genes and plays an important role in tumor development, invasion, metastasis and other processes. These molecules offer new potential opportunities for therapeutic intervention and serve as biomarkers for diagnosis. In this paper, the origin, characteristics and functions of circRNA and its role in tumor development, invasion and metastasis, diagnosis and prognosis are reviewed.

引用

页码：1305 / 1313

页数：9

共 72 条

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