Preparation and study on the solid inclusion complex of sparfloxacin with β-cyclodextrin

被引：22
|
作者：
Chao, JB [1 ]
Tong, HB [1 ]
Huang, SP [1 ]
Liu, DS [1 ]
机构：
[1] Shanxi Univ, Text & Anal Ctr, TaiYuan 030006, Peoples R China
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2004年 / 60卷 / 1-2期
关键词：
sparfloxacin; beta-CD; inclusion complex; 1D NMR; 2D NMR;
D O I：
10.1016/S1386-1425(03)00211-7
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
The interaction of sparfloxacin with beta-cyclodextrin (beta-CD) has been studied by several analytical techniques, including H-1-NMR, C-13-NMR, fluorescence spectroscopy, infrared spectroscopy, thermal analysis, and scanning electron microscope. In this paper, solid inclusion complex of sparfloxacin with beta-CD was synthesized by the coprecipitation method. In addition, the characterization of the inclusion complex has been proved by fluorimetry, Infrared, differential scanning calorimetry and 1D, 2D NMR. The experimental results confirmed the existence of l: l inclusion complex of sparfloxacin with beta-CD. The formation constant of complex was determined by fluorescence method and H-1-NMR. Spacial configuration of complex has been proposed on 2D NMR techniques. (C) 2003 Elsevier B.V. All rights reserved.
引用
收藏
页码：161 / 166
页数：6
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