Functional Peptides Encoded by Long Non-Coding RNAs in Gastrointestinal Cancer

被引：21
作者：
Chen, Yao [1 ,2 ,3 ]
Long, Weili [4 ]
Yang, Liqiong [1 ,2 ,3 ]
Zhao, Yueshui [1 ,2 ,3 ]
Wu, Xu [1 ,2 ,3 ]
Li, Mingxing [1 ,2 ,3 ]
Du, Fukuan [1 ,2 ,3 ]
Chen, Yu [1 ,2 ,3 ]
Yang, Zhihui [5 ]
Wen, Qinglian [6 ]
Yi, Tao [7 ]
Xiao, Zhangang [1 ,2 ,3 ]
Shen, Jing [1 ,2 ,3 ]
机构：
[1] Southwest Med Univ, Sch Pharm, Dept Pharmacol, Lab Mol Pharmacol, Luzhou, Peoples R China
[2] South Sichuan Inst Translat Med, Luzhou, Peoples R China
[3] Southwest Med Univ, Sch Pharm, Lab Personalised Cell Therapy & Cell Med, Luzhou, Peoples R China
[4] Southwest Med Univ, Sch Basic Med, Luzhou, Peoples R China
[5] Southwest Med Univ, Affiliated Hosp, Dept Pathol, Luzhou, Peoples R China
[6] Southwest Med Univ, Affiliated Hosp, Dept Oncol, Luzhou, Peoples R China
[7] Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Peoples R China
来源：
FRONTIERS IN ONCOLOGY | 2021年 / 11卷
基金：
中国国家自然科学基金;
关键词：
long non-coding RNA (lncRNA); ORF; small peptide; gastrointestinal cancer; function; SUPPRESSES CELL-PROLIFERATION; MESSENGER-RNA; DNA METHYLATION; GENE-EXPRESSION; POOR-PROGNOSIS; LNCRNA; PROMOTES; LINC00675; TRANSCRIPTION; EVOLUTION;
D O I：
10.3389/fonc.2021.777374
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastrointestinal cancer is by far the most common malignancy and the most common cause of cancer-related deaths worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) play an important role in the epigenetic regulation of cancer cells and regulate tumor progression by affecting chromatin modifications, gene transcription, translation, and sponge to miRNAs. In particular, lncRNA has recently been found to possess open reading frame (ORF), which can encode functional small peptides or proteins. These peptides interact with its targets to regulate transcription or the signal axis, thus promoting or inhibiting the occurrence and development of tumors. In this review, we summarize the involvement of lncRNAs and the function of lncRNAs encoded small peptides in gastrointestinal cancer.
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页数：12
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