Molecular X-ray computed tomography of myelin in a rat brain

被引：46
作者：
Jensen, T. H. [1 ]
Bech, M. [1 ,2 ]
Bunk, O. [3 ]
Menzel, A. [3 ]
Bouchet, A. [4 ,5 ]
Duc, G. Le [4 ]
Feidenhans'l, R. [1 ]
Pfeiffer, F. [2 ]
机构：
[1] Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark
[2] Tech Univ Munich, Dept Phys, D-8046 Garching, Germany
[3] Villigen PSI, Paul Scherrer Inst, Villigen, Switzerland
[4] European Synchrotron Radiat Facil, F-38043 Grenoble, France
[5] Grenoble Inst Neurosci, Team 7, Grenoble, France
来源：
NEUROIMAGE | 2011年 / 57卷 / 01期
关键词：
Molecular tomography; X-ray scattering; Myelin; X-ray computed tomography; SCATTERING; NANOSTRUCTURE; SHEATH;
D O I：
10.1016/j.neuroimage.2011.04.013
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In this work we demonstrate the feasibility of applying small-angle X-ray scattering computed tomography (SAXS-CT) for non-invasive molecular imaging of myelin sheaths in a rat brain. Our results show that the approach yields information on several quantities, including the relative myelin concentration, its periodicity, the total thickness of the myelin sheaths, and the relative concentration of cytoskeletal neurofilaments. For example the periodicity of the myelin sheaths varied in the range from 17.0 to 18.2 nm around an average of 17.6 (+/- 0.3)nm. We believe that imaging, i.e., spatially resolved measuring these quantities could provide general means for understanding the relation to a number of neurodegenerative diseases. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：124 / 129
页数：6
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