Central nervous system infection caused by Mycobacterium houstonense: A case report
被引:3
作者:
Wang, LiXia
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h-index: 0
机构:
Sichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R ChinaSichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R China
Wang, LiXia
[1
]
Wang, FaPing
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h-index: 0
机构:
Sichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R ChinaSichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R China
Wang, FaPing
[1
]
Yang, Chuan
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h-index: 0
机构:
Sichuan Univ, Frontiers Sci Ctr Dis Related Mol Network, Lab Pulm Immunol & Inflammat, Chengdu, Peoples R ChinaSichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R China
Yang, Chuan
[2
]
Luo, FengMing
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h-index: 0
机构:
Sichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R ChinaSichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R China
Luo, FengMing
[1
]
机构:
[1] Sichuan Univ, West China Hosp, Dept Resp & Crit Care Med, Chengdu, Peoples R China
[2] Sichuan Univ, Frontiers Sci Ctr Dis Related Mol Network, Lab Pulm Immunol & Inflammat, Chengdu, Peoples R China
来源:
FRONTIERS IN NEUROLOGY
|
2022年
/
13卷
基金:
中国国家自然科学基金;
关键词:
Mycobacteria houstonense;
Mycobacterium fortuitum group;
rapidly growing mycobacteria;
central nervous system infection;
next generation sequencing;
3RD BIOVARIANT COMPLEX;
DRUG SUSCEPTIBILITY;
INTERFERON-GAMMA;
TUBERCULOSIS;
RESISTANCE;
FORTUITUM;
DIAGNOSIS;
MENINGITIS;
CHELONAE;
DISEASE;
D O I:
10.3389/fneur.2022.908086
中图分类号:
R74 [神经病学与精神病学];
学科分类号:
摘要:
BackgroundMycobacterium houstonense is a rapidly growing mycobacterium (RGM) that belongs to the unnamed third biovariant complex of the Mycobacterium fortuitum group, which is rarely responsible for human infection. Approximately 76% of infections caused by the M. fortuitum group occur after open fractures or skin, soft tissue, bone, or puncture wounds. To date, only a few cases of human infectious disease caused by M. houstonense have been reported worldwide. Case presentationWe present a case of a 26-year-old man with a central nervous system (CNS) infection caused by M. houstonense. The patient was transferred to our hospital because of headaches and muscle strength changes. One month prior to presentation at our hospital, the patient was diagnosed with tuberculous meningitis at the other two hospitals, but his condition did not improve after anti-tuberculous treatment, antibiotics, and anti-viral treatment before admission to our hospital. Lumbar puncture was performed at both previous hospitals, as well as at our hospital; the results consistently indicated high cerebrospinal fluid (CSF) opening pressure. M. houstonense was detected in the CSF of the second hospital's lumbar puncture by metagenomic next-generation sequencing (mNGS) but was not identified at our hospital. The patient was discharged from our hospital after receiving non-tuberculous mycobacterium (NTM) treatment for 1 month according to the Chinese NTM guidelines. However, the patient died 20 days after discharge. ConclusionSince it is difficult to identify M. houstonense, this is the first case of human CNS infection caused by M. houstonense in China. This case may be considered by neurologists and infectious physicians when CNS infection does not respond to conventional treatment, especially in the uncommon type of NTM.
机构:
Natl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Czaja, Christopher A.
Merkel, Patricai A.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Div Pathol, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Merkel, Patricai A.
Chan, Edward D.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Chan, Edward D.
Lenz, Laurel L.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Integrated Dept Immunol, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Lenz, Laurel L.
Wolf, Molly L.
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h-index: 0
机构:
Natl Jewish Hlth, Adv Diagnost Labs, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Wolf, Molly L.
Alam, Rafeul
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Div Allergy & Immunol, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Alam, Rafeul
Frankel, Stephen K.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Frankel, Stephen K.
Fischer, Aryeh
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Div Rheumatol, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Fischer, Aryeh
Gogate, Shaila
论文数: 0引用数: 0
h-index: 0
机构:
Allergy Asthma Colorado PC, Englewood, CO USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Gogate, Shaila
Perez-Velez, Carlos M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arizona Coll Med, Banner Good Samaritan Med Ctr, Div Infect Dis, Phoenix, AZ USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Perez-Velez, Carlos M.
Knight, Vijaya
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Div Pathol, Denver, CO 80206 USA
Natl Jewish Hlth, Adv Diagnost Labs, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
机构:
Childrens Natl Med Ctr, Div Pediat Infect Dis, Washington, DC 20010 USAChildrens Natl Med Ctr, Div Pediat Infect Dis, Washington, DC 20010 USA
Goldberg, Brittany
Sichtig, Heike
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Microbiol Devices, Off In Vitro Diagnost & Radiol Hlth, Silver Spring, MD USAChildrens Natl Med Ctr, Div Pediat Infect Dis, Washington, DC 20010 USA
Sichtig, Heike
Geyer, Chelsie
论文数: 0引用数: 0
h-index: 0
机构:
Amer Soc Microbiol, Washington, DC USAChildrens Natl Med Ctr, Div Pediat Infect Dis, Washington, DC 20010 USA
Geyer, Chelsie
Ledeboer, Nathan
论文数: 0引用数: 0
h-index: 0
机构:
Med Coll Wisconsin, Dept Pathol, Milwaukee, WI 53226 USAChildrens Natl Med Ctr, Div Pediat Infect Dis, Washington, DC 20010 USA
Ledeboer, Nathan
Weinstock, George M.
论文数: 0引用数: 0
h-index: 0
机构:
Jackson Lab Genom Med, Farmington, CT 06032 USAChildrens Natl Med Ctr, Div Pediat Infect Dis, Washington, DC 20010 USA
机构:
Natl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Czaja, Christopher A.
Merkel, Patricai A.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Div Pathol, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Merkel, Patricai A.
Chan, Edward D.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Chan, Edward D.
Lenz, Laurel L.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Integrated Dept Immunol, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Lenz, Laurel L.
Wolf, Molly L.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Adv Diagnost Labs, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Wolf, Molly L.
Alam, Rafeul
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Div Allergy & Immunol, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Alam, Rafeul
Frankel, Stephen K.
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Frankel, Stephen K.
Fischer, Aryeh
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Div Rheumatol, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Fischer, Aryeh
Gogate, Shaila
论文数: 0引用数: 0
h-index: 0
机构:
Allergy Asthma Colorado PC, Englewood, CO USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Gogate, Shaila
Perez-Velez, Carlos M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Arizona Coll Med, Banner Good Samaritan Med Ctr, Div Infect Dis, Phoenix, AZ USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
Perez-Velez, Carlos M.
Knight, Vijaya
论文数: 0引用数: 0
h-index: 0
机构:
Natl Jewish Hlth, Div Pathol, Denver, CO 80206 USA
Natl Jewish Hlth, Adv Diagnost Labs, Denver, CO 80206 USANatl Jewish Hlth, Div Mycobacterial & Resp Infect, Denver, CO 80206 USA
机构:
Childrens Natl Med Ctr, Div Pediat Infect Dis, Washington, DC 20010 USAChildrens Natl Med Ctr, Div Pediat Infect Dis, Washington, DC 20010 USA
Goldberg, Brittany
Sichtig, Heike
论文数: 0引用数: 0
h-index: 0
机构:
US FDA, Div Microbiol Devices, Off In Vitro Diagnost & Radiol Hlth, Silver Spring, MD USAChildrens Natl Med Ctr, Div Pediat Infect Dis, Washington, DC 20010 USA
Sichtig, Heike
Geyer, Chelsie
论文数: 0引用数: 0
h-index: 0
机构:
Amer Soc Microbiol, Washington, DC USAChildrens Natl Med Ctr, Div Pediat Infect Dis, Washington, DC 20010 USA
Geyer, Chelsie
Ledeboer, Nathan
论文数: 0引用数: 0
h-index: 0
机构:
Med Coll Wisconsin, Dept Pathol, Milwaukee, WI 53226 USAChildrens Natl Med Ctr, Div Pediat Infect Dis, Washington, DC 20010 USA
Ledeboer, Nathan
Weinstock, George M.
论文数: 0引用数: 0
h-index: 0
机构:
Jackson Lab Genom Med, Farmington, CT 06032 USAChildrens Natl Med Ctr, Div Pediat Infect Dis, Washington, DC 20010 USA