Plant-Mediated Zinc Oxide Nanoparticles: Advances in the New Millennium towards Understanding Their Therapeutic Role in Biomedical Applications

被引：76

作者：

Murali, Mahadevamurthy ^{[1
]}

Kalegowda, Nataraj ^{[1
]}

Gowtham, Hittanahallikoppal G. ^{[2
]}

Ansari, Mohammad Azam ^{[3
]}

Alomary, Mohammad N. ^{[4
]}

Alghamdi, Saad ^{[5
]}

Shilpa, Natarajamurthy ^{[2
,6
]}

Singh, Sudarshana B. ^{[2
]}

Thriveni, M. C. ^{[7
]}

Aiyaz, Mohammed ^{[2
]}

Angaswamy, Nataraju ^{[8
]}

Lakshmidevi, Nanjaiah ^{[6
]}

Adil, Syed F. ^{[9
]}

Hatshan, Mohammad R. ^{[9
]}

Amruthesh, Kestur Nagaraj ^{[1
]}

机构：

[1] Univ Mysore, Dept Studies Bot, Appl Plant Pathol Lab, Mysuru 570006, Karnataka, India

[2] Univ Mysore, Dept Studies Biotechnol, Mysuru 570006, Karnataka, India

[3] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat IRMC, Dept Epidem Dis Res, Dammam 31441, Saudi Arabia

[4] King Abdulaziz City Sci & Technol, Life Sci & Environm Res Inst, Natl Ctr Biotechnol, POB 6086, Riyadh 11442, Saudi Arabia

[5] Umm Al Qura Univ, Fac Appl Med Sci, Lab Med Dept, POB 715, Mecca, Saudi Arabia

[6] Univ Mysore, Dept Studies Microbiol, Mysuru 570006, Karnataka, India

[7] Minist Text, Cent Silk Board, Cent Sericultural Germplasm Resources Ctr, Thally Rd, Hosur 635109, Tamil Nadu, India

[8] Karnataka State Open Univ, Dept Biochem, Mysuru 570006, Karnataka, India

[9] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia

来源：

PHARMACEUTICS | 2021年 / 13卷 / 10期

关键词：

antimicrobial; antioxidant; antidiabetic; anticancer; anti-inflammatory; drug delivery; photocatalytic; ZNO NANOPARTICLES; GREEN SYNTHESIS; LEAF EXTRACT; PHOTOCATALYTIC DEGRADATION; ANTIBACTERIAL ACTIVITY; IN-VITRO; ASSISTED SYNTHESIS; PONGAMIA-PINNATA; ANTIOXIDANT; BIOSYNTHESIS;

D O I：

10.3390/pharmaceutics13101662

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Zinc oxide nanoparticles have become one of the most popular metal oxide nanoparticles and recently emerged as a promising potential candidate in the fields of optical, electrical, food packaging, and biomedical applications due to their biocompatibility, low toxicity, and low cost. They have a role in cell apoptosis, as they trigger excessive reactive oxygen species (ROS) formation and release zinc ions (Zn2+) that induce cell death. The zinc oxide nanoparticles synthesized using the plant extracts appear to be simple, safer, sustainable, and more environmentally friendly compared to the physical and chemical routes. These biosynthesized nanoparticles possess strong biological activities and are in use for various biological applications in several industries. Initially, the present review discusses the synthesis and recent advances of zinc oxide nanoparticles from plant sources (such as leaves, stems, bark, roots, rhizomes, fruits, flowers, and seeds) and their biomedical applications (such as antimicrobial, antioxidant, antidiabetic, anticancer, anti-inflammatory, photocatalytic, wound healing, and drug delivery), followed by their mechanisms of action involved in detail. This review also covers the drug delivery application of plant-mediated zinc oxide nanoparticles, focusing on the drug-loading mechanism, stimuli-responsive controlled release, and therapeutic effect. Finally, the future direction of these synthesized zinc oxide nanoparticles' research and applications are discussed.

引用

页数：44

共 153 条

[1] Low temperature biosynthesis of crystalline zinc oxide nanoparticles from Musa acuminata peel extract for visible-light degradation of methylene blue [J].