Filovirus vaccines

被引：23

作者：

Bradfute, Steven B. ^{[1
]}

Dye, John M. ^{[1
]}

Bavari, Sina ^{[1
]}

机构：

[1] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA

来源：

HUMAN VACCINES | 2011年 / 7卷 / 06期

关键词：

ebola; ebola virus; ebolavirus; filovirid; filoviridae; filovirus; marburg virus; marburgvirus; mononegavirad; mononegavirales; mononegavirus; vaccine; EBOLA-VIRUS-INFECTION; PROTECT GUINEA-PIGS; EQUINE ENCEPHALITIS-VIRUS; T-CELL RESPONSES; MARBURG VIRUS; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; POSTEXPOSURE PROTECTION; PARTICLES PROTECT; NORTHERN ZAIRE;

D O I：

10.4161/hv.7.6.15398

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Filoviruses can cause severe and often fatal hemorrhagic fever in humans and non-human primates (NHPs). Although there are currently no clinically proven treatments for filovirus disease, much progress has been made in recent years in the discovery of therapeutics and vaccines against these viruses. A variety of vaccine platforms have been shown to be effective against filovirus infection. This review summarizes the literature in this field, focusing on vaccines that have been shown to protect NHPs from infection. Furthermore, the uses of rodent models in vaccine development, as well as correlates of immunity, are discussed.

引用

页码：701 / 711

页数：11

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