Filovirus vaccines

被引：23

作者：

Bradfute, Steven B. ^{[1
]}

Dye, John M. ^{[1
]}

Bavari, Sina ^{[1
]}

机构：

[1] USA, Med Res Inst Infect Dis, Frederick, MD 21702 USA

来源：

HUMAN VACCINES | 2011年 / 7卷 / 06期

关键词：

ebola; ebola virus; ebolavirus; filovirid; filoviridae; filovirus; marburg virus; marburgvirus; mononegavirad; mononegavirales; mononegavirus; vaccine; EBOLA-VIRUS-INFECTION; PROTECT GUINEA-PIGS; EQUINE ENCEPHALITIS-VIRUS; T-CELL RESPONSES; MARBURG VIRUS; HEMORRHAGIC-FEVER; NONHUMAN-PRIMATES; POSTEXPOSURE PROTECTION; PARTICLES PROTECT; NORTHERN ZAIRE;

D O I：

10.4161/hv.7.6.15398

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Filoviruses can cause severe and often fatal hemorrhagic fever in humans and non-human primates (NHPs). Although there are currently no clinically proven treatments for filovirus disease, much progress has been made in recent years in the discovery of therapeutics and vaccines against these viruses. A variety of vaccine platforms have been shown to be effective against filovirus infection. This review summarizes the literature in this field, focusing on vaccines that have been shown to protect NHPs from infection. Furthermore, the uses of rodent models in vaccine development, as well as correlates of immunity, are discussed.

引用

页码：701 / 711

页数：11

共 95 条

[1] Discovery of Swine as a Host for the Reston ebolavirus [J].

Barrette, Roger W. ;

Metwally, Samia A. ;

Rowland, Jessica M. ;

Xu, Lizhe ;

Zaki, Sherif R. ;

Nichol, Stuart T. ;

Rollin, Pierre E. ;

Towner, Jonathan S. ;

Shieh, Wun-Ju ;

Batten, Brigid ;

Sealy, Tara K. ;

Carrillo, Consuelo ;

Moran, Karen E. ;

Bracht, Alexa J. ;

Mayr, Gregory A. ;

Sirios-Cruz, Magdalena ;

Catbagan, Davinio P. ;

Lautner, Elizabeth A. ;

Ksiazek, Thomas G. ;

White, William R. ;

McIntosh, Michael T. .

SCIENCE, 2009, 325 (5937) :204-206

[2] PATHOLOGY OF EXPERIMENTAL EBOLA VIRUS-INFECTION IN MONKEYS [J].

BASKERVILLE, A ;

BOWEN, ETW ;

PLATT, GS ;

MCARDELL, LB ;

SIMPSON, DIH .

JOURNAL OF PATHOLOGY, 1978, 125 (03) :131-&

[3] Lipid raft microdomains: A gateway for compartmentalized trafficking of Ebola and Marburg viruses [J].

Bavari, S ;

Bosio, CM ;

Wiegand, E ;

Ruthel, G ;

Will, AB ;

Geisbert, TW ;

Hevey, M ;

Schmaljohn, C ;

Schmaljohn, A ;

Aman, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 195 (05) :593-602

[4] Ebola and Marburg virus-like particles activate human myeloid dendritic cells [J].

Bosio, CM ;

Moore, BD ;

Warfield, KL ;

Ruthel, G ;

Mohamadzadeh, M ;

Aman, MJ ;

Bavari, S .

VIROLOGY, 2004, 326 (02) :280-287

[5] A COMPARATIVE-STUDY OF STRAINS OF EBOLA VIRUS ISOLATED FROM SOUTHERN SUDAN AND NORTHERN ZAIRE IN 1976 [J].

BOWEN, ETW ;

PLATT, GS ;

LLOYD, G ;

RAYMOND, RT ;

SIMPSON, DIH .

JOURNAL OF MEDICAL VIROLOGY, 1980, 6 (02) :129-138

[6]

BOWEN ETW, 1977, LANCET, V1, P571

[7] EBOLA HEMORRHAGIC-FEVER - EXPERIMENTAL-INFECTION OF MONKEYS [J].

BOWEN, ETW ;

PLATT, GS ;

SIMPSON, DIH ;

MCARDELL, LB ;

RAYMOND, RT .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1978, 72 (02) :188-191

[8] A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever [J].

Bray, M ;

Davis, K ;

Geisbert, T ;

Schmaljohn, C ;

Huggins, J .

JOURNAL OF INFECTIOUS DISEASES, 1998, 178 (03) :651-661

[9] The role of the Type I interferon response in the resistance of mice to filovirus infection [J].

Bray, M .

JOURNAL OF GENERAL VIROLOGY, 2001, 82 :1365-1373

[10] A single intranasal inoculation with a paramyxovirus-vectored vaccine protects guinea pigs against a lethal-dose Ebola virus challenge [J].

Bukreyev, A ;

Yang, LJ ;

Zaki, SR ;

Shieh, WJ ;

Rollin, PE ;

Murphy, BR ;

Collins, PL ;

Sanchez, A .

JOURNAL OF VIROLOGY, 2006, 80 (05) :2267-2279

← 1 2 3 4 5 6 7 8 9 10 →