Secondary metabolites from Chamaedora tepejilote (Palmae) are active against Mycobacterium tuberculosis

被引：36

作者：

Jiménez, A

Meckes, M

Alvarez, V

Torres, J

Parra, R

机构：

[1] Hosp Pediat Mexico City, Ctr Med Nacl Siglo 21, IMSS, Unidad Invest Med Farmacol Prod Nat, Mexico City 06725, DF, Mexico

[2] Hosp Pediat Mexico City, Ctr Med Nacl Siglo 21, IMSS, Unidad Invest Med Enfermedades Infec & Parasita, Mexico City 06725, DF, Mexico

来源：

PHYTOTHERAPY RESEARCH | 2005年 / 19卷 / 04期

关键词：

Chamaedora tepejilote; Palmae; bioassay-guided isolation; antimycobacterial compounds; triterpenoids; ursolic acids; squalene;

D O I：

10.1002/ptr.1664

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Due to the emergence of multi-drug resistant Mycobacterium tuberculosis strains, there is an urgent need to search for new antimycobacterial drugs. The present work describes the bioactivity-guided fractionation of Chamaedora tepejilote hexane extract which led to the isolation and the characterization of squalene, farnesol, methylic ester of hexadecanoic acid, beta-sitosterol and ursolic acid. Activity against Mycobacterium tuberculosis H37Rv, determined by radiorespirometric Bactec assay, showed ursolic acid, squalene and farnesol to produce a M. tuberculosis growth inhibition of 99% at a concentration of 100 mu g/mL. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：320 / 322

页数：3