A comparative biomechanical analysis of term fetal membranes in human and domestic species

被引：14

作者：

Borazjani, Ali ^{[1
,4
]}

Weed, Benjamin C. ^{[1
,4
]}

Patnaik, Sourav S. ^{[1
]}

Feugang, Jean M. ^{[2
]}

Christiansen, David ^{[3
]}

Elder, Steven H. ^{[1
]}

Ryan, Peter L. ^{[2
,3
]}

Liao, Jun ^{[1
]}

机构：

[1] Mississippi State Univ, Dept Agr & Biol Engn, Tissue Bioengn Lab, Bagley Coll Engn,TERC & CAVS, Mississippi State, MS 39762 USA

[2] Mississippi State Univ, Coll Agr & Life Sci, Dept Anim & Dairy Sci, Mississippi State, MS 39762 USA

[3] Mississippi State Univ, Coll Vet Med, Dept Pathobiol & Populat Med, Mississippi State, MS 39762 USA

[4] OCH Reg Med Ctr, Dept Labor & Delivery, Mississippi State, MS USA

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 2011年 / 204卷 / 04期

关键词：

biomechanics; fetal membrane; PPROM; reproduction; PRETERM PREMATURE RUPTURE; MANAGEMENT; TISSUES;

D O I：

10.1016/j.ajog.2010.12.003

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

OBJECTIVE: The purpose of this study was to biomechanically characterize and compare human, porcine, equine, and ovine fetal membranes. STUDY DESIGN: Noncontact metrology was used for topographic analyses. Uniaxial tensile testing was performed to resolve specific biomechanical values. Puncture force and radial stresses were determined with biaxial puncture testing. Microstructure and surface tortuosity were analyzed histologically. RESULTS: Equine and human membranes sustained larger magnitude loading, but ovine and porcine membranes exhibited stronger material properties. Biaxial puncture validated uniaxial results; human and equine groups accommodated the largest loads but lowest stresses. Equine membranes were mostly vascularized; tortuosity was highest in porcine membranes. Species' gestation length was correlated positively with membrane thickness. CONCLUSION: The anatomy of placentation and length of species gestation show distinct relationships to membrane biomechanics. Unlike other species, human fetal membranes do not compensate for structural weakness with a thicker membrane. This finding may explain the high incidence of preterm premature rupture of membranes in humans.

引用

页码：365.e25 / 365.e36

页数：12

共 29 条

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