Dynamics of Viral Shedding and Symptoms in Patients with Asymptomatic or Mild COVID-19

被引：21

作者：

Bae, Seongman ^{[1
]}

Kim, Ji Yeun ^{[1
]}

Lim, So Yun ^{[1
]}

Park, Heedo ^{[2
,3
]}

Cha, Hye Hee ^{[1
]}

Kwon, Ji-Soo ^{[1
]}

Suh, Mi Hyun ^{[1
]}

Lee, Hyun Jung ^{[1
]}

Lim, Joon Seo ^{[4
]}

Jung, Jiwon ^{[1
]}

Kim, Min Jae ^{[1
]}

Chong, Yong Pil ^{[1
]}

Lee, Sang-Oh ^{[1
]}

Choi, Sang-Ho ^{[1
]}

Kim, Yang Soo ^{[1
]}

Lee, Ho Young ^{[2
,3
]}

Lee, Sohyun ^{[2
,3
]}

Park, Man-Seong ^{[2
,3
]}

Kim, Sung-Han ^{[1
]}

机构：

[1] Univ Ulsan, Dept Infect Dis, Asan Med Ctr, Coll Med, Seoul 05505, South Korea

[2] Korea Univ, Dept Biomed Sci, BK21 Grad Program, Coll Med, Seoul 02841, South Korea

[3] Korea Univ, Inst Viral Dis, Dept Microbiol, Biosafety Ctr,Coll Med, Seoul 02841, South Korea

[4] Univ Ulsan, Asan Inst Life Sci, Asan Med Ctr, Clin Res Ctr,Coll Med, Seoul 05505, South Korea

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 11期

基金：

新加坡国家研究基金会;

关键词：

SARS-CoV-2; presymptomatic; viral shedding; subgenomic RNA; viable culture;

D O I：

10.3390/v13112133

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We conducted a prospective cohort study at a community facility designated for the isolation of individuals with asymptomatic or mild COVID-19 between 10 January and 22 February 2021 to investigate the relationship of viral shedding with symptom changes of COVID-19. In total, 89 COVID-19 adult patients (12 asymptomatic, 16 presymptomatic, 61 symptomatic) were enrolled. Symptom scores, the genomic RNA and subgenomic RNA of SARS-CoV-2 from saliva samples with a cell culture were measured. Asymptomatic COVID-19 patients had a similar viral load to symptomatic patients during the early course of the disease, but exhibited a rapid decrease in viral load with the loss of infectivity. Subgenomic RNA and viable virus by cell culture in asymptomatic patients were detected only until 3 days after diagnosis, and the positivity of the subgenomic RNA and cell culture in symptomatic patients gradually decreased in both from 40% in the early disease course to 13% at 10 days and 4% at 8 days after the symptom onset, respectively. In conclusion, symptomatic patients have a high infectivity with high symptom scores during the early disease course and gradually lose infectivity depending on the symptom. Conversely, asymptomatic patients exhibit a rapid decrease in viral load with the loss of infectivity, despite a similar viral load during the early disease course.

引用

页数：11

共 15 条

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