Microbial transformation of Astragalus sapogenins using Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552

被引：15

作者：

Bedir, Erdal ^{[1
]}

Kula, Ceyda ^{[2
]}

Oner, Ozlem ^{[3
]}

Altas, Melis ^{[1
]}

Tag, Ozgur ^{[4
]}

Ongen, Gaye ^{[1
]}

机构：

[1] Ege Univ, Fac Engn, Dept Bioengn, TR-35100 Izmir, Turkey

[2] Marmara Univ, Fac Engn, Dept Bioengn, TR-34722 Istanbul, Turkey

[3] Ege Univ, Grad Sch Nat & Appl Sci, Dept Biotechnol, TR-35100 Izmir, Turkey

[4] Ege Univ, Grad Sch Nat & Appl Sci, Dept Chem, TR-35100 Izmir, Turkey

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2015年 / 115卷

关键词：

Astragalus; Microbial transformation; Cycloastragenol; Cyclocanthogenol; Astragenol; BIOTRANSFORMATION; ACID; CYCLOASTRAGENOL; TRITERPENOIDS;

D O I：

10.1016/j.molcatb.2015.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The microbial transformation of Astragalus sp. derived sapogenins, namely cycloastragenol, astragenol and cyclocanthogenol, by Cunninghamella blakesleeana NRRL 1369 and Glomerella fusarioides ATCC 9552 were investigated. The unique enzyme system of both fungi resulted hydroxylation, cyclization, dehydrogenation and oxidation reactions. Structures of the new metabolites were elucidated by 1-D (H-1, C-13, NOESY), 2-D NMR (DQF-COSY, HMBC, HMQC, NOESY) and HR-MS analyses. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：29 / 34

页数：6

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