Fabrication of chitosan-blend-P(LLA-CL) nanofibers by electrospinning

In the application of tissue engineering, non-woven film provide a properly environment for exists and proliferations of the tissue cells. As chitosan has well biocompatible property, and synthetic copolymer has well mechanical property and degradability, so a lot of researches focus on fabricating the tissue engineering scaffold using both of them. In this paper, a new solution system has been developed to fabricate chitosan-blend-copolymer P(LLA-CL) [50 : 50] nanofibers by electrospinning. SEM analyses showed that the acquired nanofibers were uniform with smooth surface. The degradation result has a break change in the very beginning of the degraded test, which demonstrates that the interior structures of chitosan may had been destroyed during the dissolving process. Fourier transform infrared spectra(FTIR) demonstrated that the nanofibers contained chitosan and P(LLA-CL).