The Genetics of Altitude Tolerance The Evidence for Inherited Susceptibility to Acute Mountain Sickness

被引：25

作者：

MacInnis, Martin J. ^{[1
]}

Wang, Pei ^{[1
]}

Koehle, Michael S. ^{[1
,2
]}

Rupert, Jim L. ^{[1
]}

机构：

[1] Univ British Columbia, Sch Human Kinet, Vancouver, BC V6T 1Z1, Canada

[2] Univ British Columbia, Dept Family Practice, Allan McGavin Sport Med Ctr, Vancouver, BC V6T 1Z1, Canada

来源：

JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE | 2011年 / 53卷 / 02期

关键词：

HYPOXIC VENTILATORY RESPONSE; CONVERTING ENZYME GENOTYPE; EXHALED NITRIC-OXIDE; NO ASSOCIATION; CEREBRAL EDEMA; TIBETAN HIGHLANDERS; OXYGEN-SATURATION; PULMONARY-EDEMA; SYNTHASE GENE; POLYMORPHISMS;

D O I：

10.1097/JOM.0b013e318206b112

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Objective: Acute mountain sickness (AMS) has become a significant environmental health issue as improvements in transportation, "environmental tourism," and resource development lure more people to the highlands. Whether there is a genetic contribution to AMS susceptibility is a central question in high-altitude medicine. This article provides a systematic review of the evidence supporting such an innate predisposition. Methods: Scientific literature databases were screened using the terms "acute mountain sickness/AMS" and "altitude illness" combined with the terms "DNA," "gene," "genetic," or "polymorphism." Results: Sixteen genes from a variety of pathways have been tested for association with AMS and variants in eight showed positive associations suggesting that AMS is an environmentally mediated polygenic disorder. Conclusions: The data suggest that genotype contributes to capacity to rapidly and efficiently acclimatize to altitude; nevertheless, the mechanisms by which this occurs have yet to be elucidated.

引用

页码：159 / 168

页数：10

共 101 条

[21]

Collins FS, 2001, CANCER, V91, P221, DOI 10.1002/1097-0142(20010101)91:1+<221::AID-CNCR8>3.0.CO

[22]

2-9

[23] Critique of the equivalent air altitude model [J].

Conkin, Johnny ;

Wessel, James H., III .

AVIATION SPACE AND ENVIRONMENTAL MEDICINE, 2008, 79 (10) :975-982

[24]

Daugaard M, 2007, FEBS LETT, V581, P3702, DOI [10.1016/j.febslet.2007.05.039, 10.1016/j.febsiet.2007.05.039]

[25] No association between high-altitude tolerance and the ACE I/D gene polymorphism [J].

Dehnert, C ;

Weymann, J ;

Montgomery, HE ;

Woods, D ;

Maggiorini, M ;

Scherrer, U ;

Gibbs, JSR ;

Bärtsch, P .

MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 2002, 34 (12) :1928-1933

[26]

del Rio MS, 1999, ADV EXP MED BIOL, V474, P145

[27]

Dosenko VE, 2006, ACTA BIOCHIM POL, V53, P299

[28] Two Hypoxia Sensor Genes and Their Association with Symptoms of Acute Mountain Sickness in Sherpas [J].

Droma, Yunden ;

Ota, Masao ;

Hanaoka, Masayuki ;

Katsuyama, Yoshihiko ;

Basnyat, Buddha ;

Neupane, Pritam ;

Arjyal, Amit ;

Pandit, Anil ;

Sharma, Dependra ;

Ito, Michiko ;

Kubo, Keishi .

AVIATION SPACE AND ENVIRONMENTAL MEDICINE, 2008, 79 (11) :1056-1060

[29] Early brain swelling in acute hypoxia [J].

Dubowitz, David J. ;

Dyer, Edward A. W. ;

Theilmann, Rebecca J. ;

Buxton, Richard B. ;

Hopkins, Susan R. .

JOURNAL OF APPLIED PHYSIOLOGY, 2009, 107 (01) :244-252

[30] Exhaled nitric oxide in high-altitude pulmonary edema - Role in the regulation of pulmonary vascular tone and evidence for a role against inflammation [J].

Duplain, H ;

Sartori, C ;

Lepori, M ;

Egli, M ;

Allemann, Y ;

Nicod, P ;

Scherrer, U .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (01) :221-224

← 1 2 3 4 5 6 7 8 9 10 →