Synthesis, cytotoxicity and antiviral activity of podophyllotoxin analogues modified in the E-ring

被引：37
作者：
Castro, MA
del Corral, JMM
Gordaliza, M
Gómez-Zurita, MA
de la Puente, ML
Betancur-Galvis, LA
Sierra, J
Feliciano, AS
机构：
[1] Univ Salamanca, Fac Farm, Dept Quim Farmaceut, E-37007 Salamanca, Spain
[2] Univ Antioquia, Fac Med, Grp Infecc & Canc, Medellin 1226, Colombia
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 38卷 / 10期
关键词：
podophyllotoxin; cyclolignans; E-ring modifications; cytotoxicity; Herpes simplex virus; ANTITUMOR AGENTS; DERIVATIVES; ETOPOSIDE; LIGNANS; INHIBITORS; VP-16-213; PHENOLS;
D O I：
10.1016/j.ejmech.2003.05.001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Several podophyllotoxin derivatives modified in the E-ring were prepared and evaluated for their cytotoxicity on four neoplastic cell lines (P-388, A-549, HT-29 and MEL-28) and for their antiherpetic activity against Herpes simplex virus type II. The trimethoxyphenyl moiety was oxidized to ortho-quinone and further condensed with diamines and enamines to form different heterocycles. Most of the compounds maintained their cytotoxicity at the muM level and some of them showed antiherpetic activity. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
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收藏
页码：899 / 911
页数：13
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