Clinical Onset and Multiple Sclerosis Relapse after SARS-CoV-2 Infection

被引：15

作者：

Pignolo, Antonia ^{[1
]}

Aprile, Maria ^{[1
]}

Gagliardo, Cesare ^{[1
]}

Giammanco, Giovanni Maurizio ^{[2
]}

D'Amelio, Marco ^{[1
]}

Aridon, Paolo ^{[1
]}

La Tona, Giuseppe ^{[1
]}

Salemi, Giuseppe ^{[1
]}

Ragonese, Paolo ^{[1
]}

机构：

[1] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BiND, Via Gaetano Loggia 1, I-90129 Palermo, Italy

[2] Univ Palermo, Dept Hlth Promot Mother & Child Care Internal Med, I-90129 Palermo, Italy

来源：

NEUROLOGY INTERNATIONAL | 2021年 / 13卷 / 04期

关键词：

multiple sclerosis; COVID-19; relapse; onset; vaccine;

D O I：

10.3390/neurolint13040066

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been associated with several neurological disorders including headache, facial palsy, encephalitis, stroke, demyelinating disorders. The present report will discuss cases of multiple sclerosis (MS) onset and relapse both beginning early after SARS-CoV-2 infection. In both cases, magnetic resonance imaging (MRI) showed widespread bilateral subcortical and periventricular active lesions. Serum IgG against SARS-CoV-2 Spike antigens confirmed seroconversion with titers that are considered not definitely protective against possible reinfection. We hypothesize that SARS-CoV-2 infection, as previously reported for other viruses, could drive an active inflammatory response that can contribute either to the onset of MS or its relapse. The presented data further support the importance of vaccination in individuals with MS.

引用

页码：695 / 700

页数：6

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