Association of long noncoding RNAs expression levels and their gene polymorphisms with systemic lupus erythematosus

被引：37

作者：

Li, Jun ^{[1
,2
,3
]}

Wu, Guo-Cui ^{[1
,2
]}

Zhang, Tian-Ping ^{[1
,2
]}

Yang, Xiao-Ke ^{[1
,2
]}

Chen, Shuang-Shuang ^{[1
,2
]}

Li, Lian-Ju ^{[1
,2
]}

Xu, Shu-Zhen ^{[1
,2
]}

Lv, Tian-Tian ^{[1
,2
]}

Leng, Rui-Xue ^{[1
,2
]}

Pan, Hai-Feng ^{[1
,2
]}

Ye, Dong-Qing ^{[1
,2
]}

机构：

[1] Anhui Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hefei, Anhui, Peoples R China

[2] Anhui Prov Key Lab Major Autoimmune Dis, Hefei, Anhui, Peoples R China

[3] Jiangyin Ctr Dis Control & Prevent, Jiangyin, Jiangsu, Peoples R China

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

基金：

中国国家自然科学基金;

关键词：

DISEASE-ACTIVITY; SUSCEPTIBILITY; MECHANISMS; LOCUS; ALPHA; RISK;

D O I：

10.1038/s41598-017-15156-4

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Increasing evidence has demonstrated the association between long noncoding RNAs (lncRNAs) and multiple autoimmune diseases. To explore four lncRNAs (GAS5, lnc-DC, linc0597 and linc0949) expression levels and gene polymorphisms in systemic lupus erythematosus (SLE), a two stage design was applied. In the first stage, 85 SLE patients and 71 healthy controls were enrolled to investigate the lncRNAs expression levels. Then, 1260 SLE patients and 1231 healthy controls were included to detect the single nucleotide polymorphisms (SNPs) in the differentially expressed lncRNAs identified in the first stage. Linc0597, lnc-DC and GAS5 expression levels were significantly lower in SLE patients than healthy controls (P < 0.001, P < 0.001, P = 0.003 respectively). Association of five SNPs (rs10515177, rs2070107, rs2632516, rs2877877, rs2067079) with SLE risk were analyzed. No significant association was observed between these gene polymorphisms and susceptibility to SLE (all P > 0.010), and we did not find significant association between any genotypes at five SNPs and their respective lncRNAs expression in SLE (all P > 0.010). In summary, the expression levels of linc0597, lnc-DC and GAS5 are decreased in SLE patients, but their gene polymorphisms are not associated with SLE risk, and do not influence their expression levels.

引用

页数：8

共 39 条

[21] Possible evidence of systemic lupus erythematosus and periodontal disease association mediated by Toll-like receptors 2 and 4 [J].