Prognostic status of p53 gene mutation in canine mammary carcinoma

被引:0
作者
Wakui, S
Muto, T
Yokoo, K
Yokoo, R
Takahashi, H
Masaoka, T
Hano, H
Furusato, M
机构
[1] Azabu Univ, Sch Vet Med, Comparat Toxicol Labs, Kanagawa 2298501, Japan
[2] Jikei Univ, Sch Med, Dept Pathol, Minato Ku, Tokyo 1058461, Japan
[3] Kyorin Univ, Sch Med, Dept Pathol, Mitaka, Tokyo 1818611, Japan
关键词
p53; prognosis; mammary carcinoma; dogs;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: The p53 gene mutations have been associated with the development of human breast and canine mammary neoplasms; breast carcinoma patients with alterations of p53 gene are considered to have a poor prognosis. Mammary carcinoma represents the most common malignant tumor in female dogs. However, the prognostic significance of p53 gene mutation in the dog has been unclear. Study design: The alteration in exons 5-8 of p53 gene in 69 canine mammary carcinomas were investigated by PCR-SSCP with direct sequence analysis and statistically analyzed to compare with other clinicopathological parameters including age, neuter; tumor size, stage, histology, p53 expression, recurrence and death from carcinoma. Results: 12 out of 69 (17%) carcinomas showed p53 gene mutations. After a follow-up period of 30 months, multivariate regression analysis revealed that p53 gene mutation was only an independent risk factor for increased risk of the recurrence and death from mammary carcinoma. Conclusion: The p53 gene alterations might contribute to the prognostic status in canine mammary carcinomas, in a way comparable to that of human tumors.
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页码:611 / 616
页数:6
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