Design, synthesis and biological evaluation of new ganglioside GM3 analogues as potential agents for cancer therapy

被引:6
作者
Zheng, Changping [1 ]
Huang, Ruyi [2 ]
Bavaro, Teodora [4 ]
Terreni, Marco [4 ]
Sollogoub, Matthieu [1 ]
Xu, Jianhua [2 ]
Zhang, Yongmin [1 ,3 ]
机构
[1] Sorbonne Univ, IPCM, CNRS, UMR 8232, 4 Pl Jussieu, F-75005 Paris, France
[2] Fujian Med Univ, Sch Pharm, Fuljan Prov Key Lab Nat Med Pharmacol, Fuzhou 350122, Fujian, Peoples R China
[3] Jianghan Univ, Inst Interdisciplinary Res, Wuhan Econ & Technol Dev Zone, Wuhan 430056, Peoples R China
[4] Univ Pavia, Drug Sci Dept, Viale Taramelli 12, I-27100 Pavia, Italy
关键词
GM3; analogues; Synthesis; Cancer; Antitumor; Anti-proliferation; Anti-migration; CELL MOTILITY; GROWTH; SIALYLATION; DOMAIN; ASSAY;
D O I
10.1016/j.ejmech.2020.112065
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Ganglioside GM3 is well known as a tumor-associated carbohydrate antigen on several types of tumors. Many studies have demonstrated that GM3 plays roles in cells proliferation, adhesion, motility and differentiation, which is involved in the process of cancer development. In the present study, we developed methods to synthesize GM3 analogues conveniently. By enzymatic hydrolysis and chemical procedures, two novel analogues and two known analogues were synthesized, containing lactose and glucosamine. Then anti-proliferation and anti-migration activities were evaluated by cytotoxicity assays and wound healing tests, and the data demonstrated that these analogues exhibited anticancer activities. Based on our previous studies, the structure-activity relationships were discussed. This study could provide valuable sight to find new antitumor agents for cancer therapy. (C) 2020 Elsevier Masson SAS. All rights reserved.
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收藏
页数:10
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