Benign epilepsy with centrotemporal spikes - Current concepts of diagnosis and treatment

被引:25
作者
Dryzalowski, P. [1 ]
Jozwiak, S. [1 ]
Franckiewicz, M. [1 ]
Strzelecka, J. [1 ]
机构
[1] Med Univ Warsaw, Pediat Neurol & Pediat Clin, Zwirki I Wigury 61 St, PL-02091 Warsaw, Poland
关键词
BECTS; Epilepsy; Genetics; Diagnosis; Treatment; CENTRO-TEMPORAL SPIKES; POTASSIUM CHANNEL GENE; ROLANDIC EPILEPSY; CHILDHOOD EPILEPSY; FOCAL EPILEPSIES; BINDING-SITE; CHILDREN; RECEPTOR; MUTATION; GRIN2A;
D O I
10.1016/j.pjnns.2018.08.010
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Benign epilepsy with centrotemporal spikes (BECTS) is the most common focal epilepsy of the childhood and also one of the best known. It has a proclivity to start at a particular age and remit spontaneously before adolescence. Majority of patients may avoid long-term treatment, because of the mild course and very good outcome. Only few patients may present cognitive deficits if the proper treatment is not implied. BECTS is a part of heterogeneous group of syndromes that consists of Landau- Kleffner Syndrome (LKS), Continuous Spike-and-Wave during Sleep (CSWS) and Atypical benign partial epilepsy (ABPE). These syndromes may be also a result of various trajectories that BECTS may evolve to. Disease is suggested to have genetic origins, as some patients have relatives with different types of epilepsy. The discovery of the pathogenic mechanism of the disease and implementation of targeted therapy belong to the main challenges in the treatment of these patients. (C) 2018 Polish Neurological Society. Published by Elsevier Sp. z o.o. All rights reserved.
引用
收藏
页码:677 / 689
页数:13
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