A Novel Defined Super-Enhancer Associated Gene Signature to Predict Prognosis in Patients With Diffuse Large B-Cell Lymphoma

被引:10
作者
Xu, Hong [1 ]
Li, Yuhang [1 ]
Jiang, Yanan [1 ]
Wang, Jinhuan [2 ]
Sun, Huimeng [1 ]
Wu, Wenqi [1 ]
Lv, Yangyang [1 ]
Liu, Su [1 ]
Zhai, Yixin [1 ]
Tian, LinYan [1 ]
Li, Lanfang [3 ]
Zhao, Zhigang [1 ]
机构
[1] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Tianjins Clin Res Ctr Canc, Dept Hematol,Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China
[2] Second Hosp Tianjin Med Univ, Inst Urol, Dept Oncol, Tianjin, Peoples R China
[3] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Tianjins Clin Res Ctr Canc, Dept Lymphoma,Key Lab Canc Prevent & Therapy, Tianjin, Peoples R China
基金
中国国家自然科学基金;
关键词
super-enhancer; LASSO; diffuse large B-cell lymphoma; prognostic model; overall survival; EXPRESSION; AUTOPHAGY; IDENTITY;
D O I
10.3389/fgene.2022.827840
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Background: Diffuse large B-cell lymphoma (DLBCL) is a genetically heterogeneous disease that can have profound differences in survival outcomes. A variety of powerful prognostic factors and models have been constructed; however, the development of more accurate prognosis prediction and targeted treatment for DLBCL still faces challenges. An explosion of research on super-enhancer (SE)-associated genes provide the possibility to use in prognostication for cancer patients. Here, we aimed to establish a novel effective prognostic model using SE-associated genes from DLBCL.Methods: A total of 1,105 DLBCL patients from the Gene Expression Omnibus database were included in this study and were divided into a training set and a validation set. A total of 11 SE-associated genes (BCL2, SPAG16, PXK, BTG1, LRRC37A2, EXT1, TGFBR2, ANKRD12, MYCBP2, PAX5, and MYC) were initially screened and identified by the least absolute shrinkage and selection operator (Lasso) penalized Cox regression, univariate and multivariate Cox regression analysis. Finally, a risk score model based on these 11 genes was constructed.Results: Kaplan-Meier (K-M) curves showed that the low-risk group appeared to have better clinical survival outcomes. The excellent performance of the model was determined via time-dependent receiver operating characteristic (ROC) curves. A nomogram based on the polygenic risk score was further established to promote reliable prognostic prediction. This study proposed that the SE-associated-gene risk signature can effectively predict the response to chemotherapy in DLBCL patients.Conclusion: A novel and reliable SE-associated-gene signature that can effectively classify DLBCL patients into high-risk and low-risk groups in terms of overall survival was developed, which may assist clinicians in the treatment of DLBCL.
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页数:15
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