Structural and Molecular Biology of a Protein-Polymerizing Nanomachine for Pilus Biogenesis

被引：16
作者：
Waksman, Gabriel [1 ,2 ]
机构：
[1] Birkbeck Coll, Inst Struct & Mol Biol, Malet St, London WC1E 7HX, England
[2] UCL, Inst Struct & Mol Biol, Gower St, London WC1E 6BT, England
来源：
JOURNAL OF MOLECULAR BIOLOGY | 2017年 / 429卷 / 17期
基金：
英国医学研究理事会;
关键词：
Pilus biogenesis; Usher; Chaperone; DNA polymerase I; Nanomachine; UROPATHOGENIC ESCHERICHIA-COLI; DONOR-STRAND EXCHANGE; DNA-POLYMERASE-I; CHAPERONE-ADHESIN COMPLEX; BACTERIAL OUTER-MEMBRANE; URINARY-TRACT-INFECTION; DRIVES FIBER FORMATION; USHER N-TERMINUS; CRYSTAL-STRUCTURE; FIMD USHER;
D O I：
10.1016/j.jmb.2017.05.016
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Bacteria produce protein polymers on their surface called pill or fimbriae that serve either as attachment devices or as conduits for secreted substrates. This review will focus on the chaperone usher pathway of pilus biogenesis, a widespread assembly line for pilus production at the surface of Gram-negative bacteria and the archetypical protein-polymerizing nanomachine. Comparison with other nanomachines polymerizing other types of biological units, such as nucleotides during DNA replication, provides some unifying principles as to how multidomain proteins assemble biological polymers. (C) 2017 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
引用
收藏
页码：2654 / 2666
页数：13
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