The calcium channel blocker nifedipine is widely used in children with systemic hypertension; however, because of the short duration of action, three to four daily doses of the standard preparation are required. Amlodipine once-daily, a calcium channel blocker structurally related to nifedipine with an excellent bioavailability and a long elimination half-time, has been shown to reduce blood pressure in adults. No information is available on the use of amlodipine in childhood. The effects of amlodipine once-daily (5 to 10 mg) were therefore assessed in 28 paediatric patients with hypertension. Amlodipine was withdrawn in five patients who experienced oedema and flushing. In the remaining 23 patients blood pressure was significantly reduced 3 weeks after amlodipine (on average by 7/5 mm Hg) and further decreased at 12 weeks (by 21/12 mm Hg). Heart rate and body weight were unchanged. In eight patients concomitantly treated with cyclosporine, the blood level of this agent was stable throughout the study, thus not requiring any dose adjustment.
机构:
Univ Hosp, Dept Internal Med, Subdiv Nephrol, Maastricht, NetherlandsAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
van Hooff, Johannes
Van der Walt, Isak
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机构:
Jacaranda Hosp, Pretoria, South AfricaAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Van der Walt, Isak
Kallmeyer, Jeffrey
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机构:
St Augustines Hosp, Chelmsford Med Ctr, Durban, South AfricaAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Kallmeyer, Jeffrey
Miller, Derek
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机构:
Christiaan Barnard Mem Hosp, Cape Town, South AfricaAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Miller, Derek
Dawood, Shabbir
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机构:
St Augustines Hosp, Chelmsford Med Ctr, Durban, South AfricaAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Dawood, Shabbir
Moosa, M. Rafique
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机构:
Univ Stellenbosch, Dept Med, Cape Town, South Africa
Tygerberg Hosp, Cape Town, South AfricaAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Moosa, M. Rafique
Christiaans, Maarten
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机构:
Univ Hosp, Dept Internal Med, Subdiv Nephrol, Maastricht, NetherlandsAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Christiaans, Maarten
Karpf, Carmen
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机构:
Astellas GmbH, Munich, GermanyAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Karpf, Carmen
Undre, Nasrullah
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机构:
Astellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, EnglandAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
机构:
Univ Hosp, Dept Internal Med, Subdiv Nephrol, Maastricht, NetherlandsAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
van Hooff, Johannes
Van der Walt, Isak
论文数: 0引用数: 0
h-index: 0
机构:
Jacaranda Hosp, Pretoria, South AfricaAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Van der Walt, Isak
Kallmeyer, Jeffrey
论文数: 0引用数: 0
h-index: 0
机构:
St Augustines Hosp, Chelmsford Med Ctr, Durban, South AfricaAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Kallmeyer, Jeffrey
Miller, Derek
论文数: 0引用数: 0
h-index: 0
机构:
Christiaan Barnard Mem Hosp, Cape Town, South AfricaAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Miller, Derek
Dawood, Shabbir
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h-index: 0
机构:
St Augustines Hosp, Chelmsford Med Ctr, Durban, South AfricaAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Dawood, Shabbir
Moosa, M. Rafique
论文数: 0引用数: 0
h-index: 0
机构:
Univ Stellenbosch, Dept Med, Cape Town, South Africa
Tygerberg Hosp, Cape Town, South AfricaAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Moosa, M. Rafique
Christiaans, Maarten
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp, Dept Internal Med, Subdiv Nephrol, Maastricht, NetherlandsAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Christiaans, Maarten
Karpf, Carmen
论文数: 0引用数: 0
h-index: 0
机构:
Astellas GmbH, Munich, GermanyAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England
Karpf, Carmen
Undre, Nasrullah
论文数: 0引用数: 0
h-index: 0
机构:
Astellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, EnglandAstellas Pharma Europe Ltd, Staines TW18 3AZ, Middx, England