DNA cleavage mediated by water-soluble manganese corrole

被引:30
作者
Lu, Jun [1 ]
Liu, Hai Yang [1 ]
Shi, Lei [1 ]
Wang, Xiang Li [1 ]
Ying, Xiao [2 ]
Zhang, Lei [1 ]
Ji, Liang Nian [3 ]
Zang, Lin Quan [4 ]
Chang, Chi K. [5 ]
机构
[1] S China Univ Technol, Coll Chem & Chem Engn, Guangzhou 510641, Guangdong, Peoples R China
[2] S China Univ Technol, Dept Appl Phys, Guangzhou 510641, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, MOE Lab Bioinorgan & Synthet Chem, State Key Lab Optoelect Mat & Technol, Guangzhou 510275, Guangdong, Peoples R China
[4] Guangdong Pharmaceut Univ, Dept Pharmacol, Guangzhou 510006, Guangdong, Peoples R China
[5] Michigan State Univ, Dept Chem, E Lansing, MI 48824 USA
基金
中国国家自然科学基金;
关键词
Corrole; Manganese; DNA; Oxidative cleavage; PORPHYRIN; BINDING;
D O I
10.1016/j.cclet.2010.09.005
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The DNA nuclease-like activity of a water soluble manganese corrole 5, 10, 15-tris(N-methyl-4-pyridyl)- corrolatomanganese(III) ((MnTMPyC)-T-III) has been investigated. (MnTMPyC)-T-III may bind strongly to DNA via outside groove binding mode as indicated by absorption spectra, viscosity measurements and CD spectra. (MnTMPyC)-T-III exhibited excellent catalytic activity in the DNA oxidative cleavage in the presence of hydroperoxide. (C) 2010 Hai Yang Liu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.
引用
收藏
页码:101 / 104
页数:4
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