Magnesium supplementation for glycemic status in women with gestational diabetes: a systematic review and meta-analysis

被引:5
|
作者
Tan, Xiaoqing [1 ]
Huang, Yi [1 ]
机构
[1] Univ Chinese Acad Sci, Chongqing Gen Hosp, Dept Obstet & Gynecol, Chongqing, Peoples R China
关键词
Gestational diabetes; magnesium supplementation; glycemic status; randomized controlled trials; INSULIN-RESISTANCE; PREGNANT-WOMEN; MELLITUS; OUTCOMES; EXERCISE; IMPACT; TRIALS; INTERVENTION; HYPERTENSION; ASSOCIATION;
D O I
10.1080/09513590.2021.1988558
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective The effect of magnesium supplementation on glycemic status in women with gestational diabetes remains controversial and this meta-analysis aims to explore the efficacy of magnesium supplementation for gestational diabetes. Methods We have searched PubMed, Excerpta Medica database, Web of science, Elton B. Stephens. Company, and Cochrane library databases. The meta-analysis included randomized controlled trials (RCTs) assessing the effect of magnesium supplementation for gestational diabetes and was performed using the random-effect model. Results Four RCTs were included in the meta-analysis. Overall, compared with placebo in gestational diabetes, magnesium supplementation was associated with significantly reduced fasting plasma glucose (standard mean difference [SMD] = -0.99; 95% confidence interval [CI] = -1.28 to -0.70; p < .00001), serum insulin (SMD = -0.75; 95% CI = -1.24 to -0.26; p = .003), homeostasis model assessment of insulin resistance (SMD = -0.74; 95% CI = -1.10 to -0.39; p < .0001) and increased quantitative insulin sensitivity check index (SMD = 0.47; 95% CI = 0.12 to 0.82; p = .008). In addition, low-density lipoprotein-cholesterol (SMD = -0.39; 95% CI = -0.73 to -0.04; p = .03) and total cholesterol (SMD = -0.62; 95% CI = -0.97 to -0.27; p = .0005) were also obviously decreased in the magnesium group than those in the control group. Conclusion Magnesium supplementation benefits glycemic control for gestational diabetes.
引用
收藏
页码:202 / 206
页数:5
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