Gingival crevicular fluid interleukin-8 and lipoxin A4 levels of smokers and nonsmokers with different periodontal status: a cross-sectional study

被引:19
作者
Lutfioglu, M. [1 ]
Aydogdu, A. [2 ]
Sakallioglu, E. E. [1 ]
Alacam, H. [3 ]
Pamuk, F. [4 ]
机构
[1] Ondokuz Mayis Univ, Dept Periodontol, Fac Dent, Samsun, Turkey
[2] Biruni Univ, Dept Periodontol, Fac Dent, Istanbul, Turkey
[3] Hacettepe Univ, Dept Med Biochem, Fac Med, Ankara, Turkey
[4] Istanbul Aydin Univ, Dept Periodontol, Fac Dent, Istanbul, Turkey
关键词
inflammatory mediator; inflammation; periodontal disease; smoking; interleukin; 8; lipoxin A4; AGGRESSIVE PERIODONTITIS; PORPHYROMONAS-GINGIVALIS; ENVIRONMENTAL-FACTORS; CYTOKINE PROFILE; INFLAMMATION; SMOKING; NEUTROPHILS; RESOLUTION; MECHANISMS; EXPRESSION;
D O I
10.1111/jre.12324
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Background and ObjectiveSmoking is an important risk factor for periodontal disease and effects the pathogenesis of the disease. This study evaluated the impact of smoking on gingival crevicular fluid interleukin-8 (IL-8) and lipoxin A(4) (LxA(4)) levels in patients with and without periodontal disease. Material and MethodsA total of 122 participants were grouped as follows: smokers with generalized aggressive periodontitis (S-GAgP, n = 15); smokers with chronic periodontitis (S-CP, n = 17); smokers with gingivitis (SG, n = 15); smokers classified as periodontally healthy (SH, n = 15); nonsmokers with generalized aggressive periodontitis (N-GAgP, n = 15); nonsmokers with chronic periodontitis (N-CP, n = 15); nonsmokers with gingivitis (NG, n = 15); and nonsmokers classified as periodontally healthy (NH, n = 15). Gingival index, plaque index, probing pocket depth and clinical attachment level were recorded. Gingival crevicular fluid IL-8 and LxA4 levels were analyzed by ELISA. ResultsGingival crevicular fluid IL-8 levels varied among groups, as follows: S-GAgP>S-CP>SG>SH and N-GAgP>N-CP>NG>NH. The gingival crevicular fluid IL-8 levels were significantly higher in the S-GAgP group compared with the N-GAgP group and in the S-CP group compared with the N-CP group (p < 0.05); differences between the SG and NG and the SH and NH groups were not statistically significant (p > 0.05). Gingival crevicular fluid LxA(4) levels also varied among groups, but in an inverse direction when compared with the IL-8 levels, as follows: S-GAgP<S-CP<SG and N-GAgP<N-CP<NG. (The gingival crevicular fluid LxA(4) levels in SH and NH groups were below the limits of detection.) The gingival crevicular fluid LxA(4) levels were significantly lower in the S-GAgP group than in the N-GAgP group and in the S-CP group than in the N-CP group (p < 0.05); differences between the SG and NG groups were not statistically significant (p > 0.05). ConclusionThe study findings suggest that the observed increases in gingival crevicular fluid IL-8 levels and decreases in gingival crevicular fluid LxA(4) levels reflect changes in immune and inflammatory responses that occur as a result of smoking.
引用
收藏
页码:471 / 480
页数:10
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