Strategies for the synthesis of N-(azacycloalkyl)bisindolylmaleimides:: selective inhibitors of PKCβ

被引：22

作者：

Faul, MM ^{[1
]}

Grutsch, JL ^{[1
]}

Kobierski, ME ^{[1
]}

Kopach, ME ^{[1
]}

Krumrich, CA ^{[1
]}

Staszak, MA ^{[1
]}

Udodong, U ^{[1
]}

Vicenzi, JT ^{[1
]}

Sullivan, KA ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Global Chem Proc Res & Dev, Indianapolis, IN 46285 USA

来源：

TETRAHEDRON | 2003年 / 59卷 / 36期

关键词：

N-(azacycloalkyl)bisindolylmaleimides; angiogenesis; vascular endothelial growth factor;

D O I：

10.1016/S0040-4020(03)00973-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-(Azacycloalkyl)bisindolylmaleimides 1 have been identified to be selective inhibitors of PKCbeta. This manuscript will describe the synthetic approaches employed to prepare this class of compounds that resulted in development of efficient methods for preparation of N-(azacycloalkyl) indole 5, indole-3-acetamide 8 and indole-3-glyoxylate ester 4 derivatives. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：7215 / 7229

页数：15

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