Attention and regional cerebral blood flow in posttraumatic stress disorder patients with substance abuse histories

被引：70
作者：
Semple, WE
Goyer, PF
McCormick, R
ComptonToth, B
Morris, E
Donovan, B
Muswick, G
Nelson, D
Garnett, ML
Sharkoff, J
Leisure, G
Miraldi, F
Schulz, SC
机构：
[1] CASE WESTERN RESERVE UNIV,DEPT PSYCHIAT,CLEVELAND,OH 44106
[2] CASE WESTERN RESERVE UNIV,DEPT RADIOL,CLEVELAND,OH 44106
来源：
PSYCHIATRY RESEARCH-NEUROIMAGING | 1996年 / 67卷 / 01期
关键词：
positron emission tomography; parietal cortex; continuous performance task;
D O I：
10.1016/0925-4927(96)02735-7
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Performance on an attentional task was assessed in posttraumatic stress disorder patients with substance abuse histories (PTSD-SA). Positron emission tomography (PET) was used to measure concurrent regional cerebral blood flow (rCBF). Eight male PTSD-SA patients and eight normal subjects each received three serial PET scans with O-15-labeled water under the following conditions: (1) resting, (2) auditory continuous performance task (ACPT1), and (3) repeat auditory task (ACPT2). PTSD-SA patients made more errors of commission on the ACPT than normal subjects. Examination of right frontal and parietal cortex ACPT task substrates revealed decreased parietal blood flow in PTSD-SA, which may represent a pathophysiology for poor attentional task performance in PTSD-SA. Attentional problems may underlie other symptomatology in PTSD.
引用
收藏
页码：17 / 28
页数：12
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